Anti-ASK1 (phospho S966)抗体(ab39402)
Key features and details
- Rabbit polyclonal to ASK1 (phospho S966)
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ASK1 (phospho S966)抗体
参阅全部 ASK1 一抗 -
描述
兔多克隆抗体to ASK1 (phospho S966) -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse
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免疫原
Synthetic peptide corresponding to Human ASK1 aa 950-1050 (phospho S966).
Database link: Q99683 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
ab39402 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non phosphopeptide was removed by chromatography using non phosphopeptide corresponding to the phosphorylation site. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab39402于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death. -
组织特异性
Abundantly expressed in heart and pancreas. -
序列相似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain. -
翻译后修饰
Dephosphorylated and activated by PGAM5. - Information by UniProt
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数据库链接
- Entrez Gene: 4217 Human
- Entrez Gene: 26408 Mouse
- Omim: 602448 Human
- SwissProt: Q99683 Human
- SwissProt: O35099 Mouse
- Unigene: 186486 Human
- Unigene: 6595 Mouse
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别名
- Apoptosis signal regulating kinase 1 antibody
- Apoptosis signal-regulating kinase 1 antibody
- ASK 1 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASK1 (phospho S966) antibody (ab39402)ab39402, at a 1/100 dilution, staining human ASK1 in breast carcinoma tissue by Immunohistochemistry, Paraffin embedded tissue.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASK1 (phospho S966) antibody (ab39402)ab39402, at a 1/100 dilution, staining human ASK1 in breast carcinoma tissue (treated with synthesized phosphopeptide) by Immunohistochemistry, Paraffin embedded tissue.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab39402 被引用在 1 文献中.
- Aytaç PS et al. Novel triazolothiadiazines act as potent anticancer agents in liver cancer cells through Akt and ASK-1 proteins. Bioorg Med Chem 24:858-72 (2016). PubMed: 26810835