AB157102

Anti-ASCC1抗体

Name: ASCC1抗体 (ab157102)| Abcam中文官网
Brand: Abcam Limited
SKU: AB157102
Price: 4606 CNY
Availability: InStock

Anti-ASCC1 antibody

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(1 Publication)

Rabbit Polyclonal ASCC1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ASCC1 aa 1-50.

查看别名

CGI-18, ASCC1, Activating signal cointegrator 1 complex subunit 1, ASC-1 complex subunit p50, Trip4 complex subunit p50

1 Images

Unknown

Western blot - Anti-ASCC1 antibody (AB157102)

All lanes:

Western blot - Anti-ASCC1 antibody (ab157102) at 0.4 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

293T whole cell lysate at 50 µg

Lane 4:

Jurkat whole cell lysate at 50 µg

Predicted band size: 45 kDa

true

Exposure time: 3min

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human ASCC1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q8N9N2

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Common marmoset": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab157102 was affinity purified using an epitope specific to ASCC1 immobilized on solid support.

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ASCC1 also known as Activating Signal Cointegrator 1 Complex Subunit 1 serves as a part of an important protein complex involved in transcriptional regulation. This protein weighs approximately 86 kilodaltons and exhibits expression in various tissues including the heart and skeletal muscles. ASCC1 acts mechanically by contributing to the remodeling of chromatin assisting in the process of transcriptional activation by modifying how genes are accessed within the chromatin structure.

Biological function summary

ASCC1 plays an important role in the functioning of the ASC-1 complex which includes other associated subunits such as ASCC2 and ASCC3. This complex is involved in the regulation of gene expression by influencing the transcriptional machinery. Through interaction with transcriptional coactivators ASCC1 modulates the transcription of specific genes aiding in cellular response mechanisms.

Pathways

Researchers have identified ASCC1 as pivotal in the DNA repair process and the transcription-coupled nucleotide excision repair pathway. Within the DNA repair pathway ASCC1 collaborates with proteins such as XPC in addressing DNA damage and maintaining genomic stability. This integration into critical pathways illustrates its influence on cellular processes that protect the genomic integrity from various types of damage.

Scientists link mutations in ASCC1 to esophageal cancer and spinal muscular atrophy. In esophageal cancer altered ASCC1 expression influences tumorigenic pathways often in conjunction with proteins such as p53. Similarly dysfunction in spinal muscular atrophy involves protein partners where ASCC1 abnormalities disrupt normal cellular mechanisms resulting in the disease's characteristic symptoms. Understanding these connections offers potential insights into therapeutic approaches targeting ASCC1-related pathways.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Plays a role in DNA damage repair as component of the ASCC complex (PubMed : 29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed : 12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.

See full target information ASCC1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell 188:5384-5402.e25 PubMed40701149

2025

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress.

Applications

Unspecified application

Species

Unspecified reactive species

Erica Wolin,Jimmy K Guo,Mario R Blanco,Isabel N Goronzy,Darvesh Gorhe,Wenzhao Dong,Andrew A Perez,Abdurrahman Keskin,Elizabeth Valenzuela,Ahmed A Abdou,Carl R Urbinati,Ross Kaufhold,H Tomas Rube,Jailson Brito Querido,Mitchell Guttman,Marko Jovanovic

View all publications

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Abcam Product Promise

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Anti-ASCC1抗体

Anti-ASCC1 antibody

Western blot - Anti-ASCC1 antibody (AB157102)