AB200370

Anti-ASB2抗体

Name: ASB2抗体 (ab200370)| Abcam中文官网
Brand: Abcam Limited
SKU: AB200370
Price: 4697 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-ASB2 antibody

(1 Review)

(1 Publication)

Rabbit Polyclonal ASB2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ASB2.

查看别名

Ankyrin repeat and SOCS box protein 2, ASB-2, ASB2

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASB2 antibody (AB200370)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASB2 antibody (AB200370)

Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue labeling ASB2 with ab200370 at a 1/50 dilution.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human ASB2. The exact immunogen used to generate this antibody is proprietary information.

Q96Q27

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ASB2 also known as ankyrin repeat and SOCS box-containing protein 2 plays a role mechanically as part of the E3 ubiquitin ligase complex. It facilitates the tagging of proteins for degradation via the ubiquitin-proteasome system. ASB2 has a molecular mass of approximately 57 kDa and exhibits robust expression in hematopoietic cells particularly within the bone marrow.

Biological function summary

ASB2 modulates cellular differentiation and it is often associated with lineage determination in hematopoietic cells. As a component of the ubiquitin ligase complex it performs a critical role in regulating protein stability by promoting ubiquitination. ASB2 interacts with several cellular proteins and contributes to the balance of protein degradation ensuring proper cell function and responses to various stimuli.

Pathways

ASB2 integrates into ubiquitin-mediated proteolysis and hematopoietic cell development pathways. It affects protein turnover and modulates signaling pathways essential for cell cycle regulation. The ASB2 protein interacts with others such as substrates in the ubiquitination process contributing to maintaining cellular homeostasis and promoting normal cellular activities.

ASB2 connections emerge in leukemia and anemia where its dysregulation impacts disease progression. In leukemia altered ASB2 expression disrupts normal cell differentiation suggesting a role in malignant transformation. This protein also associates with components of the proteolysis pathway implicating faulty protein degradation processes in anemia. Understanding ASB2 interactions may provide insights into therapeutic approaches for these conditions.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed : 15590664, PubMed : 16325183). Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2 (PubMed : 21119685). Required during embryonic heart development for complete heart looping (By similarity). Required for cardiomyocyte differentiation (PubMed : 32179481).. Isoform 1. Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA (PubMed : 19300455). Also targets DES for proteasomal degradation (By similarity). Acts as a negative regulator of skeletal muscle mass (By similarity).. Isoform 2. Targets filamins FLNA and FLNB for proteasomal degradation (PubMed : 21737450, PubMed : 22916308, PubMed : 24044920, PubMed : 24052262). This leads to enhanced adhesion of hematopoietic cells to fibronectin (PubMed : 21737450). Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes (By similarity). Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix (By similarity). Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells (PubMed : 22916308).

See full target information ASB2

style

left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:7324 PubMed39183203

2024

Multi-omics profiling of retinal pigment epithelium reveals enhancer-driven activation of RANK-NFATc1 signaling in traumatic proliferative vitreoretinopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Mengyu Liao,Xu Zhu,Yumei Lu,Xiaoping Yi,Youhui Hu,Yumeng Zhao,Zhisheng Ye,Xu Guo,Minghui Liang,Xin Jin,Hong Zhang,Xiaohong Wang,Ziming Zhao,Yupeng Chen,Hua Yan

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ASB2抗体

Anti-ASB2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASB2 antibody (AB200370)