AB70122

Anti-ARNT2抗体

Name: ARNT2抗体 (ab70122)| Abcam中文官网
Brand: Abcam Limited
SKU: AB70122
Price: 4606 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-ARNT2 antibody

(1 Review)

(2 Publications)

Rabbit Polyclonal ARNT2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ARNT2.

查看别名

BHLHE1, KIAA0307, ARNT2, Aryl hydrocarbon receptor nuclear translocator 2, ARNT protein 2, Class E basic helix-loop-helix protein 1, bHLHe1

1 Images

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Western blot - Anti-ARNT2 antibody (AB70122)

All lanes:

Western blot - Anti-ARNT2 antibody (ab70122) at 1/500 dilution

Lane 1:

Jurkat cell extract at 30 µg

Lane 2:

293 cell extract at 30 µg

Lane 3:

Jurkat cell extract at 30 µg with immunising peptide

Predicted band size: 79 kDa

Observed band size: 79 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human ARNT2. The exact immunogen used to generate this antibody is proprietary information.

Q9HBZ2

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab70122 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ARNT2 also known as Aryl Hydrocarbon Receptor Nuclear Translocator 2 plays a role in transcription regulation by partnering with other bHLH-PAS proteins. Weighing approximately 88 kDa ARNT2 is mainly found in the brain and kidneys. This protein forms a heterodimer with other proteins such as HIF-1α which enables it to regulate gene expression in response to environmental signals.

Biological function summary

ARNT2 functions as a transcriptional regulator within cellular systems. It is a part of the hypoxia-inducible factor (HIF) complex which is involved in responding to low oxygen levels in cells. ARNT2 contributes to the activation of genes that help cells adapt to hypoxic conditions and it plays a role in neuronal development and function. The involvement of ARNT2 in these processes is critical for normal physiological functions.

Pathways

ARNT2 links closely with the hypoxia signaling pathway contributing to oxygen homeostasis. It interacts with proteins like HIF-1α to activate transcription of genes involved in angiogenesis metabolism and erythropoiesis. Another significant pathway involving ARNT2 is related to circadian rhythm regulation where it partners with CLOCK and BMAL1 proteins influencing daily biological cycles.

ARNT2 has been associated with conditions like neurodevelopmental disorders and certain types of cancer. Mutations or dysregulation of ARNT2 may connect to neurodevelopmental issues likely through its interactions with proteins such as HIF-1α impacting brain function. In cancer ARNT2's involvement in hypoxia pathways can affect tumor growth and survival linking it to potential therapeutic targets.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed : 24022475). Specifically recognizes the xenobiotic response element (XRE).

See full target information ARNT2

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Disease models & mechanisms 11: PubMed30563851

2018

A viable hypomorphic mutation causes hyperphagic obesity, diabetes and hepatic steatosis.

Applications

Unspecified application

Species

Unspecified reactive species

Emre E Turer,Miguel San Miguel,Kuan-Wen Wang,William McAlpine,Feiya Ou,Xiaohong Li,Miao Tang,Zhao Zang,Jianhui Wang,Braden Hayse,Bret Evers,Xiaoming Zhan,Jamie Russell,Bruce Beutler

PloS one 8:e56949 PubMed23437279

2013

ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.

Applications

WB, IF

Species

Unspecified reactive species, Unspecified reactive species

Hwa J Choi,Timothy A Sanders,Kathryn V Tormos,Kurosh Ameri,Justin D Tsai,Angela M Park,Julissa Gonzalez,Anthony M Rajah,Xiaowei Liu,Diana M Quinonez,Paolo F Rinaudo,Emin Maltepe

View all publications

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Abcam Product Promise

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Anti-ARNT2抗体

Anti-ARNT2 antibody

Western blot - Anti-ARNT2 antibody (AB70122)