AB224825

Anti-ARL6IP2抗体

Name: ARL6IP2抗体 (ab224825)| Abcam中文官网
Brand: Abcam Limited
SKU: AB224825
Price: 4748 CNY
Availability: InStock

Anti-ARL6IP2 antibody

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(2 Publications)

Rabbit Polyclonal ARL6IP2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ATL2 aa 400-450.

查看别名

ARL6IP2, ATL2, Atlastin-2, ADP-ribosylation factor-like protein 6-interacting protein 2, ARL-6-interacting protein 2, Aip-2

2 Images

Supplier Data

Immunoprecipitation - Anti-ARL6IP2 antibody (AB224825)

ARL6IP2 was immunoprecipitated from Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab224825 at 6 μg/mg lysate. Western blot was performed from the immunoprecipitate using ab224825 at 0.4 μg/ml.

Lane 1 : ab224825 IP in Jurkat whole cell lysate.

Lane 2 : Control IgG IP in Jurkat whole cell lysate.

Detection : Chemiluminescence with exposure time of 10 seconds.

All lanes:

Immunoprecipitation - Anti-ARL6IP2 antibody (ab224825)

Predicted band size: 66 kDa

false

Supplier Data

Western blot - Anti-ARL6IP2 antibody (AB224825)

All lanes:

Western blot - Anti-ARL6IP2 antibody (ab224825) at 0.04 µg/mL

Lane 1:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Lane 2:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 15 µg

Lane 3:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Lane 4:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Predicted band size: 66 kDa

true

Exposure time: 30s

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IP, WB

applications

免疫原

Synthetic Peptide within Human ATL2 aa 400-450. The exact immunogen used to generate this antibody is proprietary information.

Q8NHH9

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ARL6IP2 also known as ADP-ribosylation-like factor 6 interacting protein 2 is a protein involved in various cellular processes. It has a mass of approximately 25 kDa and is expressed in the endoplasmic reticulum. This protein interacts with lipid-raft-associated proteins playing an important role in membrane dynamics and vesicular trafficking. Researchers have observed it in tissues that exhibit high secretory activity which suggests a function associated with protein transport or modification processes within the cell.

Biological function summary

ARL6IP2 interacts with components of the endoplasmic reticulum to maintain cellular homeostasis and structural integrity. It may be part of larger protein complexes involved in intracellular transport. This protein aids in regulating vesicle formation and trafficking which are essential for efficient cellular communication and nutrient delivery. Its ability to reorganize membrane components allows cells to respond to environmental changes effectively facilitating adaptive responses and cellular survival.

Pathways

ARL6IP2 plays a role in the endocytic and secretory pathways. It works alongside other proteins like ARF proteins and clathrin orchestrating trafficking processes that modulate membrane composition and vesicle transport. These pathways are important for normal cellular functioning and involve coordinated interactions with multiple proteins to maintain cellular equilibrium. ARL6IP2's role in these pathways exemplifies its importance in cellular dynamics and intracellular signaling.

Studies suggest links between ARL6IP2 and certain neurodegenerative conditions and cancer. Research indicates alterations in ARL6IP2 expression levels might contribute to the progression of diseases like Alzheimer's due to its involvement in cellular trafficking and membrane stability. The protein's connection to disorders often involves interactions with other proteins such as beta-amyloid precursor protein in Alzheimer's indicating its roles in disease mechanisms and pathogenesis. Understanding these interactions provides insights into developing strategies for therapeutic interventions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed : 18270207, PubMed : 19665976, PubMed : 27619977).

See full target information ATL2

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 43:114214 PubMed38761375

2024

TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks.

Applications

Unspecified application

Species

Unspecified reactive species

Mathéa Geraud,Agnese Cristini,Simona Salimbeni,Nicolas Bery,Virginie Jouffret,Marco Russo,Andrea Carla Ajello,Lara Fernandez Martinez,Jessica Marinello,Pierre Cordelier,Didier Trouche,Gilles Favre,Estelle Nicolas,Giovanni Capranico,Olivier Sordet

Archives of rheumatology 38:119-128 PubMed37235116

2023

MiR-30e-5p deficiency exerts an inhibitory effect on inflammation in rheumatoid arthritis via regulating Atl2 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Shanshan Liu,Kai Wang,Ju Li,Yan Liu,Zhongyuan Zhang,Deqian Meng

View all publications

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Anti-ARL6IP2抗体

Anti-ARL6IP2 antibody

Immunoprecipitation - Anti-ARL6IP2 antibody (AB224825)

Western blot - Anti-ARL6IP2 antibody (AB224825)