AB108205

重组Anti-Apolipoprotein CIII抗体[EPR1371(2)]

Anti-Apolipoprotein CIII antibody [EPR1371(2)]

RabMAb
Recombinant
了解详情

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(4 Publications)

Rabbit Recombinant Monoclonal Apolipoprotein CIII antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications.

查看别名

Apolipoprotein C-III, Apo-CIII, ApoC-III, Apolipoprotein C3, APOC3

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apolipoprotein CIII antibody [EPR1371(2)] (AB108205)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apolipoprotein CIII antibody [EPR1371(2)] (AB108205)

ab108205 at 1/250 dilution staining Apolipoprotein CIII in paraffin-embedded Human liver tissue by immunohistochemistry.

Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Unknown

Western blot - Anti-Apolipoprotein CIII antibody [EPR1371(2)] (AB108205)

All lanes:

Western blot - Anti-Apolipoprotein CIII antibody [EPR1371(2)] (ab108205) at 1/1000 dilution

Lane 1:

Human plasma at 10 µg

Lane 2:

HDL recombinant protein at 10 µg

Predicted band size: 11 kDa

false

不同偶联物与剂型 (2)

Carrier free

Anti-Apolipoprotein CIII antibody [EPR1371(2)] - BSA and Azide free
Carrier free

Anti-Apolipoprotein CIII antibody [EPR1371(2)] - BSA and Azide free (Capture)

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR1371(2)

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/250 - 1/500", "IHCP-species-notes": "Heat up to 98 degrees C, below boiling, and then let cool for 10-20 min.", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "" } } }

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产品详情

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Apolipoprotein CIII also known as Apo C-III or ApoC3 is an apolipoprotein with a molecular mass of approximately 8.8 kDa. It is synthesized in the liver and intestine and circulates in the bloodstream primarily as part of very low-density lipoproteins (VLDL) and high-density lipoproteins (HDL). Its main role involves the regulation of lipid metabolism particularly in relation to triglyceride-rich particles. Apo C-III serves as an inhibitor of lipoprotein lipase an enzyme essential for the hydrolysis of triglycerides into free fatty acids.

Biological function summary

Apolipoprotein CIII plays a pivotal role in lipid and lipoprotein metabolism. It is not part of a large protein complex but interacts with lipoproteins as a modulatory protein. Apo C-III affects triglyceride metabolism by delaying the clearance of VLDL and enhancing hepatic triglyceride secretion. Additionally it modulates the uptake of lipoprotein remnants by liver receptors thereby influencing the plasma levels of triglycerides and cholesterol.

Pathways

Apolipoprotein CIII is involved in the regulation of lipid metabolic pathways. It plays a role in the lipoprotein assembly pathway and the triglyceride biosynthetic process. This protein impacts the interaction between lipoprotein lipase and its substrates hindering enzyme activity which leads to elevated plasma triglyceride levels. It relates closely to other apolipoproteins such as apolipoprotein E which also participates in lipid transport and metabolism although with distinct functions and regulatory mechanisms.

Apolipoprotein CIII is implicated in conditions like hypertriglyceridemia and cardiovascular disease. Elevated levels of Apo C-III contribute to high triglyceride levels promoting atherosclerosis development due to the retention of triglyceride-rich lipoproteins in the bloodstream. This association links it to cardiovascular disease risk where its role contrasts with proteins like apolipoprotein AI which is mainly involved in protective effects via HDL metabolism. Understanding the modulation of Apo C-III levels offers potential therapeutic avenues for managing these lipid-related disorders.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed : 18201179, PubMed : 22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed : 18201179, PubMed : 22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed : 18201179, PubMed : 22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed : 18201179, PubMed : 22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed : 18408013).

See full target information Apolipoprotein C-III

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:32986 PubMed41006587

2025

Overexpression of alcohol dehydrogenase 1 A inhibits the progress of triple negative breast cancer via Wnt/β-catenin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Lihong Su,Chunlin Qiao,Jin Luo,Bianling Zhu,Yunxiao Liu

Life science alliance 8: PubMed39578076

2024

SPHK1/S1PR1/PPAR-α axis restores TJs between uroepithelium providing new ideas for IC/BPS treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Junjie Zhang,Qingyu Ge,Tianpeng Du,Yuhao Kuang,Zongyao Fan,Xinyi Jia,Wenjin Gu,Zhengsen Chen,Zhongqing Wei,Baixin Shen

Heliyon 9:e22084 PubMed38058614

2023

KIAA1429 facilitates progression of hepatocellular carcinoma by modulating m6A levels in HPN.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Meng,Wenwen Yang,Jinchao Li,Wei Chai

Proteomics. Clinical applications 14:e1900062 PubMed31532894

2019

Serum Small Extracellular Vesicles Proteome of Tuberculosis Patients Demonstrated Deregulated Immune Response.

Applications

Unspecified application

Species

Unspecified reactive species

Rakesh Arya,Deepti Dabral,Hossain Md Faruquee,Himangshu Mazumdar,Saurav Jyoti Patgiri,Trinayan Deka,Rumi Basumatary,Rukuwe-U Kupa,Chayale Semy,Wetetsho Kapfo,Kevideme Liegise,Inderjeet Kaur,Tenzin Choedon,Purnima Kumar,Rajendra Kumar Behera,Pranjal Deori,Reema Nath,Kerekha Khalo,Lahari Saikia,Vinotsole Khamo,Ranjan Kumar Nanda

View all publications

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重组Anti-Apolipoprotein CIII抗体[EPR1371(2)]