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AB77358

Anti-Apolipoprotein A V/APOA5抗体

Anti-Apolipoprotein A V/APOA5 antibody

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(1 Publication)

Goat Polyclonal Apolipoprotein A V/APOA5 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human APOA5.

查看别名

RAP3, UNQ411/PRO773, APOA5, Apolipoprotein A-V, Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3

1 Images
Western blot - Anti-Apolipoprotein A V/APOA5 antibody (AB77358)
  • WB

Unknown

Western blot - Anti-Apolipoprotein A V/APOA5 antibody (AB77358)

All lanes:

Western blot - Anti-Apolipoprotein A V/APOA5 antibody (ab77358) at 0.3 µg/mL

All lanes:

human liver lysate in RIPA buffer at 35 µg

Predicted band size: 41 kDa

Observed band size: 38 kDa

false

关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Synthetic Peptide within Human APOA5. The exact immunogen used to generate this antibody is proprietary information.

Q6Q788

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替代产品

Primary Antibodies

AB115772

Anti-Apolipoprotein A V/APOA5 antibody [2G1H11, 1F1E8]

Sandwich ELISA - Anti-Apolipoprotein A V/APOA5 antibody [2G1H11, 1F1E8] (AB115772)

  • 5
  • 1
Primary Antibodies

AB239579

Anti-Apolipoprotein A V/APOA5 antibody [C6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apolipoprotein A V/APOA5 antibody [C6] (AB239579)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB183597

Anti-Apolipoprotein E antibody [EPR19392]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-Apolipoprotein E antibody [EPR19392] (AB183597)

  • 0
  • 0
Proteins & Peptides

AB174391

Recombinant Human Apolipoprotein A V/APOA5 - BSA and Azide free (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Apolipoprotein A V/APOA5 - BSA and Azide free (denatured) (His tag N-Terminus) (AB174391)

  • 0
  • 0
Primary Antibodies

AB312318

Anti-Apolipoprotein B antibody [EPR27473-49]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-Apolipoprotein B antibody [EPR27473-49] (AB312318)

  • 0
  • 0
Primary Antibodies

AB52945

Anti-Apolipoprotein A I antibody [EP1368Y]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Apolipoprotein A I antibody [EP1368Y] (AB52945)

  • 4
  • 9
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.3-1 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Baboon": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
存储溶液
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Apolipoprotein A V also known as APOA5 plays a critical role in lipid metabolism. This protein possesses a molecular weight of approximately 39 kDa and is mainly expressed in the liver. APOA5 modulates the plasma triglyceride levels by enhancing the uptake and clearance of triglyceride-rich lipoproteins. The protein is located at the surface of these lipoproteins facilitating their interaction with receptors and enzymes like lipoprotein lipase.
Biological function summary

APOA5 influences triglyceride metabolism and is part of the HDL particle complex. It interacts directly with lipoprotein lipase to promote the hydrolysis of triglycerides into free fatty acids. This hydrolytic action aids in reducing triglyceride levels in the plasma. APOA5 also indirectly influences very-low-density lipoprotein (VLDL) metabolism reinforcing its role in lipid regulation.

Pathways

APOA5 integrates into the lipoprotein metabolic pathway and the PPAR signaling pathway. In the lipoprotein metabolic pathway APOA5 works with proteins like APOC3 to influence triglyceride homeostasis. This protein is modulated by PPAR-alpha helping control lipid metabolism and energy homeostasis. Its role in these pathways highlights its impact on triglyceride-rich lipoprotein metabolism positioning it as an important player in maintaining lipid balance.

APOA5 strongly associates with hypertriglyceridemia and cardiovascular disease. Variations in the APOA5 gene can lead to abnormal plasma triglyceride levels contributing to the development of hypertriglyceridemia. Additionally APOA5's connection with APOE proteins through lipid metabolism pathways can influence susceptibility to cardiovascular disorders. Understanding the interactions and mutations within APOA5 provides insights into the mechanisms contributing to these disease states.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin : cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed : 17326667).
See full target information APOA5
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cellular physiology and biochemistry : internation 51:2309-2323 PubMed30537737

2018

The Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis via Ca2+ CaMKII-Dependent MAPK and Akt/ mTOR Pathways in a Rat Osteoarthritis Model.

Applications

Unspecified application

Species

Unspecified reactive species

Yingliang Wei,Zhaofeng Jin,He Zhang,Shang Piao,Jinghan Lu,Lunhao Bai
View all publications
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