Anti-Apc10抗体(ab126204)
Key features and details
- Rabbit polyclonal to Apc10
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Apc10抗体
参阅全部 Apc10 一抗 -
描述
兔多克隆抗体to Apc10 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Chicken, Cow, Xenopus laevis
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免疫原
Recombinant fragment, corresponding to a region within amino acids 1-135 of Human Apc10 (Q9UM13).
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阳性对照
- MCF7 whole cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab126204于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/3000. Predicted molecular weight: 21 kDa.
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| 说明 |
|---|
|
WB
1/500 - 1/3000. Predicted molecular weight: 21 kDa. |
靶标
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功能
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. -
通路
Protein modification; protein ubiquitination. -
序列相似性
Belongs to the APC10 family.
Contains 1 DOC domain. - Information by UniProt
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数据库链接
- Entrez Gene: 783986 Cow
- Entrez Gene: 10393 Human
- Entrez Gene: 68999 Mouse
- Entrez Gene: 361389 Rat
- Entrez Gene: 734319 Xenopus laevis
- Omim: 613745 Human
- SwissProt: Q2YDH1 Cow
- SwissProt: Q9UM13 Human
see all -
形式
It localises to Cytosol and nucleoplasm. -
别名
- ANAPC 10 antibody
- anapc10 antibody
- Anaphase promoting complex 10 antibody
see all
图片
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Western blot - Anti-Apc10 antibody (ab126204)Anti-Apc10 antibody (ab126204) at 1/1000 dilution + MCF7 whole cell lysate at 30 µg
Predicted band size: 21 kDa
12% SDS PAGE
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab126204 被引用在 1 文献中.
- Sako K et al. Emi2 mediates meiotic MII arrest by competitively inhibiting the binding of Ube2S to the APC/C. Nat Commun 5:3667 (2014). PubMed: 24770399