APC Anti-IL-2 Receptor alpha抗体[7D4] (ab25486)
Key features and details
- APC Rat monoclonal [7D4] to IL-2 Receptor alpha
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgM
Related conjugates and formulations
概述
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产品名称
APC Anti-IL-2 Receptor alpha抗体[7D4]
参阅全部 IL-2 Receptor alpha 一抗 -
描述
APC大鼠单克隆抗体[7D4] to IL-2 Receptor alpha -
宿主
Rat -
偶联物
APC. Ex: 645nm, Em: 660nm -
特异性
ab25486 reacts with the low affinity alpha chain IL-2 receptor (IL-2Ralpha). -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse IL-2 Receptor alpha.
Database link: P01590 -
表位
ab25486 reacts with an epitope between amino acids 125 and 212. -
阳性对照
- IHC-P: colon tissue. ICC/IF: U-251 MG cells. WB: ZIP-3 overexpressed HEK-293T whole cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. Store In the Dark. -
存储溶液
pH: 7.3
Preservative: 0.09% Sodium azide
Constituents: PBS, 16% Sucrose
Stabilising agent. -
Concentration information loading... -
纯度
Purified IgM -
克隆
单克隆 -
克隆编号
7D4 -
同种型
IgM -
轻链类型
kappa -
研究领域
相关产品
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Alternative Versions
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab25486于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
Use 0.2µg for 106 cells.
|
| 说明 |
|---|
|
Flow Cyt
Use 0.2µg for 106 cells. |
靶标
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功能
Receptor for interleukin-2. -
疾病相关
Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. -
序列相似性
Contains 2 Sushi (CCP/SCR) domains. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 16184 Mouse
- SwissProt: P01590 Mouse
- Unigene: 915 Mouse
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别名
- Interleukin 2 receptor alpha chain antibody
- CD25 antibody
- CD25 antigen antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab25486 被引用在 4 文献中.
- Anraku M et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignant mesothelioma. J Immunol 185:956-66 (2010). Flow Cyt ; Mouse . PubMed: 20548032
- Lorenzo F et al. Structure-function study of the p55 subunit of murine IL-2 receptor by epitope mapping. J Immunol 147:2970-7 (1991). PubMed: 1717581
- Moreau JL et al. Monoclonal antibodies identify three epitope clusters on the mouse p55 subunit of the interleukin 2 receptor: relationship to the interleukin 2-binding site. Eur J Immunol 17:929-35 (1987). PubMed: 2440696
- Ortega G et al. The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. J Immunol 133:1970-5 (1984). PubMed: 6206144