JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB41459

APC Anti-CD62L抗体[MEL-14]

APC Anti-CD62L antibody [MEL-14]

4

(1 Review)

|

(5 Publications)

Rat Monoclonal CD62L antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 5 publications. Immunogen corresponding to Cell preparation containing CD62L protein.
1 Images
Flow Cytometry - APC Anti-CD62L antibody [MEL-14] (AB41459)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-CD62L antibody [MEL-14] (AB41459)

Flow Cytometry of C57Bl/6 splenocytes labeling CD62L with ab41459 at 0.06μg (solid line), or Rat IgG2a isotype control at 0.06μg (dashed line).

不同偶联物与剂型 (6)

  • Unconjugated

    Anti-CD62L antibody [MEL-14]

  • redFluor™ 710

    redFluor™ 710 Anti-CD62L antibody [MEL-14]

  • 778 PE/Cy7®

    PE/Cy7® Anti-CD62L antibody [MEL-14]

  • Biotin

    Biotin Anti-CD62L antibody [MEL-14]

  • 519 FITC

    FITC Anti-CD62L antibody [MEL-14]

  • Carrier free

    Anti-CD62L antibody [MEL-14] - BSA and Azide free

关键信息

宿主种属

Rat

克隆

Monoclonal

克隆号

MEL-14

亚型

IgG2a

轻链类型

kappa

偶联物

APC

激发波长/发射波长

Ex: 650nm, Em: 660nm

不含载体蛋白

No

反应种属

Mouse

应用

Flow Cyt

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>" } } }
style
left-column
style
left-column

产品详情

style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification
存储溶液
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.14% Sodium dihydrogen phosphate, 0.1% Gelatin
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD62L also known as L-selectin is a cell adhesion molecule with a mass of approximately 74 kDa. It is part of the L-selectin family and is found on the surface of leukocytes including T cells B cells neutrophils and monocytes. Mouse models frequently study CD62L under the name "MEL-14". CD62L plays an important role in mediating the adhesion and rolling of leukocytes on blood vessel endothelial cells during the immune response. Its structure allows it to interact specifically with carbohydrates on endothelial cells facilitating the initial steps of leukocyte extravasation into tissues.
Biological function summary

CD62L is involved in the migration of leukocytes into lymphoid tissues and sites of inflammation. It is not known to be part of a larger protein complex; rather it functions independently on the cell membrane. CD62L also assists in the homing of naive lymphocytes to peripheral lymph nodes. The molecule regulates how immune cells enter tissues through high endothelial venules acting as a critical entry point for leukocyte trafficking.

Pathways

CD62L contributes significantly to the immune trafficking pathway and leukocyte adhesion cascade. It works closely with other adhesion molecules like CD44 and CD54 (ICAM-1) which are important within the context of cellular responses during inflammation. CD62L's function in these pathways ensures that immune cells are properly directed to areas where they are needed most whether that is secondary lymphoid organs or inflamed tissues.

CD62L expression and function have been associated with inflammatory conditions and certain immune-related pathologies such as multiple sclerosis and rheumatoid arthritis. Altered CD62L expression can affect lymphocyte homing potentially playing a role in the pathogenesis of these conditions. The role of CD62L is also linked to proteins like CD44 which can modulate cell interactions and have overlapping functions in disease mechanisms influencing disease progression or resolution.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

See full target information CD62L
style
left-column

文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 13:1042-1058 PubMed36793856

2023

Low-dose X-ray radiodynamic therapy solely based on gold nanoclusters for efficient treatment of deep hypoxic solid tumors combined with enhanced antitumor immune response.

Applications

Unspecified application

Species

Unspecified reactive species

Shengcang Zhu,Feihong Yan,Lulu Yang,Bingyi Li,Ruxian Xue,Wenwen Yu,Yu Wang,Lu Huang,Lijun Wang,Rongcheng Han,Yuqiang Jiang

The Journal of experimental medicine 181:669-75 PubMed7530761

1995

Sequential contribution of L- and P-selectin to leukocyte rolling in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

K Ley,D C Bullard,M L Arbonés,R Bosse,D Vestweber,T F Tedder,A L Beaudet

Cell 61:611-22 PubMed1693096

1990

The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding.

Applications

Unspecified application

Species

Unspecified reactive species

M H Siegelman,I C Cheng,I L Weissman,E K Wakeland

Journal of immunology (Baltimore, Md. : 1950) 138:4313-21 PubMed3584977

1987

Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes.

Applications

Unspecified application

Species

Unspecified reactive species

D M Lewinsohn,R F Bargatze,E C Butcher

Nature 304:30-4 PubMed6866086

1983

A cell-surface molecule involved in organ-specific homing of lymphocytes.

Applications

Unspecified application

Species

Unspecified reactive species

W M Gallatin,I L Weissman,E C Butcher
View all publications
style
left-column
style
left-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。
style
left-column
style
right-column

关联产品

Select an associated product type
Alternative Product
Primary Antibodies

AB218829

Anti-CD62L antibody [EPR22188-297]

primary-antibodies

cd62l-antibody-epr22188-297-ab218829

0

(0 reviews)

Alternative Product
Primary Antibodies

AB245124

Anti-CD62L antibody [EPR22188-297] - BSA and Azide free

primary-antibodies

cd62l-antibody-epr22188-297-bsa-and-azide-free-ab245124

0

(0 reviews)

Alternative Version
Primary Antibodies

AB242077

redFluor™ 710 Anti-CD62L antibody [MEL-14]

primary-antibodies

redfluor-710-cd62l-antibody-mel-14-ab242077

0

(0 reviews)

Alternative Version
Primary Antibodies

AB25569

PE/Cy7® Anti-CD62L antibody [MEL-14]

primary-antibodies

pe-cy7-cd62l-antibody-mel-14-ab25569

5

(1 reviews)

Alternative Version
Primary Antibodies

AB24969

Biotin Anti-CD62L antibody [MEL-14]

primary-antibodies

biotin-cd62l-antibody-mel-14-ab24969

0

(0 reviews)

Alternative Version
Primary Antibodies

AB24876

FITC Anti-CD62L antibody [MEL-14]

primary-antibodies

fitc-cd62l-antibody-mel-14-ab24876

0

(0 reviews)

Alternative Version
Primary Antibodies

AB256147

Anti-CD62L antibody [MEL-14] - BSA and Azide free

primary-antibodies

cd62l-antibody-mel-14-bsa-and-azide-free-ab256147

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com