AB134489

APC Anti-CD200 / OX2抗体[OX104]

Name: APC Anti-CD200 / OX2抗体[OX104] (ab134489)| Abcam中文官网
Brand: Abcam Limited
SKU: AB134489
Price: 2861 CNY
Availability: InStock
Rating: 3 (4 reviews)

APC Anti-CD200 / OX2 antibody [OX104]

(4 Reviews)

(2 Publications)

Mouse Monoclonal CD200 / OX2 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human, Cynomolgus monkey samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CD200.

查看别名

CD200, MOX1, MOX2, My033, OX-2 membrane glycoprotein

2 Images

Flow Cytometry - APC Anti-CD200 / OX2 antibody [OX104] (AB134489)

Flow Cyt

Unknown

Flow Cytometry - APC Anti-CD200 / OX2 antibody [OX104] (AB134489)

Flow cytometry analysis of normal Human peripheral blood cells with Anti-Human CD19 PE and 0.25 µg of Mouse IgG1 kappa Isotype Control APC (left) or 5 µl (0.25 µg) ab134489 (right). Cells in the lymphocyte gate were used for analysis.

Flow Cyt

AbReview33846****

Flow Cytometry - APC Anti-CD200 / OX2 antibody [OX104] (AB134489)

Flow cytometry analysis of Cynomolgus monkey whole blood after red blod cell lysis, staining CD200 / OX2 with ab134489. Cells were fixed with paraformaldehyde. The sample was incubated with the primary antibody (1/100 in 1% BSA in PBS) for 1 hour at 4°C. .

Gating Strategy : Live lymphocytes

This image is courtesy of an anonymous Abreview

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

OX104

亚型

IgG1

偶联物

APC

激发波长/发射波长

Ex: 650nm, Em: 660nm

不含载体蛋白

反应种属

Human, Cynomolgus monkey

应用

Flow Cyt

applications

免疫原

Recombinant Fragment Protein within Human CD200. The exact immunogen used to generate this antibody is proprietary information.

P41217

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "5 µL for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/apc-mouse-fab2-igg1-kappa-monoclonal-15h6-isotype-control-ab37391'>ab37391</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" }, "Cynomolgus monkey": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "5 µL for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/apc-mouse-fab2-igg1-kappa-monoclonal-15h6-isotype-control-ab37391'>ab37391</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein G

存储溶液

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS, 0.2% BSA

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.

Biological function summary

CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.

Pathways

CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.

CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

See full target information CD200

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 11:13159 PubMed34162924

2021

Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical therapeutic efficacy evaluation.

Applications

Unspecified application

Species

Unspecified reactive species

Victoria L Slaughter,John W Rumsey,Rachel Boone,Duaa Malik,Yunqing Cai,Narasimhan Narasimhan Sriram,Christopher J Long,Christopher W McAleer,Stephen Lambert,Michael L Shuler,J J Hickman

Stem cell research & therapy 10:155 PubMed31151466

2019

Feasibility of repairing full-thickness skin defects by iPSC-derived epithelial stem cells seeded on a human acellular amniotic membrane.

Applications

Unspecified application

Species

Unspecified reactive species

Huateng Zhou,Lixiang Wang,Cui Zhang,Jintao Hu,Jianlin Chen,Weibin Du,Fei Liu,Weifan Ren,Jinfu Wang,Renfu Quan

View all publications

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For licensing inquiries, please contact partnerships@abcam.com

APC Anti-CD200 / OX2抗体[OX104]

APC Anti-CD200 / OX2 antibody [OX104]

Flow Cytometry - APC Anti-CD200 / OX2 antibody [OX104] (AB134489)

Flow Cytometry - APC Anti-CD200 / OX2 antibody [OX104] (AB134489)

关键信息

宿主种属

克隆

克隆号

亚型

偶联物

激发波长/发射波长

不含载体蛋白

反应种属

应用

免疫原