AB72040

Anti-APC 抗体

Name: APC抗体 (ab72040)| Abcam中文官网
Brand: Abcam Limited
SKU: AB72040
Price: 4869 CNY
Availability: InStock
Rating: 5 (2 reviews)

Anti-APC antibody

(2 Reviews)

(4 Publications)

Rabbit Polyclonal APC antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human APC.

查看别名

DP2.5, APC, Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 2.5

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APC antibody (AB72040)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APC antibody (AB72040)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling APC with ab72040 at 1/1000 (1µg/ml). Detection : DAB.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

Synthetic Peptide within Human APC. The exact immunogen used to generate this antibody is proprietary information.

P25054

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/2000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Platypus": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rhesus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus tropicalis": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab72040 was affinity purified using an epitope specific to APC immobilized on solid support.

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: PBS, 1.815% Tris, 1.764% Sodium citrate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed : 17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed : 17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

See full target information APC

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 12:2678 PubMed33976153

2021

Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Marija Kojic,Tomasz Gawda,Monika Gaik,Alexander Begg,Anna Salerno-Kochan,Nyoman D Kurniawan,Alun Jones,Katarzyna Drożdżyk,Anna Kościelniak,Andrzej Chramiec-Głąbik,Soroor Hediyeh-Zadeh,Maria Kasherman,Woo Jun Shim,Enakshi Sinniah,Laura A Genovesi,Rannvá K Abrahamsen,Christina D Fenger,Camilla G Madsen,Julie S Cohen,Ali Fatemi,Zornitza Stark,Sebastian Lunke,Joy Lee,Jonas K Hansen,Martin F Boxill,Boris Keren,Isabelle Marey,Margarita S Saenz,Kathleen Brown,Suzanne A Alexander,Sergey Mureev,Alina Batzilla,Melissa J Davis,Michael Piper,Mikael Bodén,Thomas H J Burne,Nathan J Palpant,Rikke S Møller,Sebastian Glatt,Brandon J Wainwright

Aging 12:23808-23821 PubMed33176278

2020

Effect of Klotho protein during porcine oocyte maturation via Wnt signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Eui Hyun Kim,Anukul Taweechaipaisankul,Muhammad Rosyid Ridlo,Geon A Kim,Byeong Chun Lee

Theranostics 10:74-90 PubMed31903107

2020

Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion.

Applications

Unspecified application

Species

Unspecified reactive species

Lin-Yuan Zhang,Jiaji Pan,Muyassar Mamtilahun,Yuan Zhu,Liping Wang,Ashwin Venkatesh,Rubing Shi,Xuanqiang Tu,Kunlin Jin,Yongting Wang,Zhijun Zhang,Guo-Yuan Yang

Scientific reports 9:10783 PubMed31346222

2019

GRP78 translocation to the cell surface and O-GlcNAcylation of VE-Cadherin contribute to ER stress-mediated endothelial permeability.

Applications

Unspecified application

Species

Unspecified reactive species

Raji Lenin,Peter G Nagy,Kumar Abhiram Jha,Rajashekhar Gangaraju

View all publications

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