Anti-APAF1抗体(ab2001)
Key features and details
- Rabbit polyclonal to APAF1
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-APAF1抗体
参阅全部 APAF1 一抗 -
描述
兔多克隆抗体to APAF1 -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human APAF1 aa 12-28 (N terminal).
Sequence:HREALEKDIKTSYIMDHC
(Peptide available asab7873) -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
靶标
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功能
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. -
组织特异性
Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver. -
序列相似性
Contains 1 CARD domain.
Contains 1 NB-ARC domain.
Contains 13 WD repeats. -
结构域
The CARD domain mediates interaction with APIP. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 317 Human
- Omim: 602233 Human
- SwissProt: O14727 Human
- Unigene: 728891 Human
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别名
- APAF 1 antibody
- Apaf-1 antibody
- APAF_HUMAN antibody
see all
图片
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Lane 1 : Anti-APAF1 antibody (ab2001) at 1 µg/ml
Lane 2 : Anti-APAF1 antibody (ab2001) at 2 µg/ml
All lanes : K562 cell lysates -
ab2001 at 1µg/ml staining Apaf1 in human heart tissue by IHC
数据表及文件
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SDS download
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Datasheet download
文献 (29)
ab2001 被引用在 29 文献中.
- Luo M et al. H Long Terminal Repeat-Associating 2 (HHLA2) is a Biomarker of Advanced Stage Hepatocellular Carcinoma and Promotes Tumor Cell Development In Vitro. Med Sci Monit 27:e930215 (2021). PubMed: 33990536
- Guo Z et al. MiR-502 Suppresses TNF-a-Induced Nucleus Pulposus Cell Apoptosis by Targeting TARF2. Biomed Res Int 2021:5558369 (2021). PubMed: 33869626
- Cavalcante RS et al. STAT3/NF-?B signalling disruption in M2 tumour-associated macrophages is a major target of PLGA nanocarriers/PD-L1 antibody immunomodulatory therapy in breast cancer. Br J Pharmacol 178:2284-2304 (2021). PubMed: 33434950
- Yue M et al. NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation. RNA Biol 18:1981-1995 (2021). PubMed: 33530829
- Wang C et al. Combinative treatment of Curdione and docetaxel triggers reactive oxygen species (ROS)-mediated intrinsic apoptosis of triple-negative breast cancer cells. Bioengineered 12:10037-10048 (2021). PubMed: 34666596