Anti-Angiotensin II Type 1 Receptor抗体(ab124505)
Key features and details
- Rabbit polyclonal to Angiotensin II Type 1 Receptor
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Mouse
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Angiotensin II Type 1 Receptor抗体
参阅全部 Angiotensin II Type 1 Receptor 一抗 -
描述
兔多克隆抗体to Angiotensin II Type 1 Receptor -
宿主
Rabbit -
特异性
ab124505 is specific for Angiotensin II Type 1 Receptor (AGTR1) and will not cross-react with AGTR2. -
经测试应用
适用于: ICC/IF, WB, IHC-Pmore details -
种属反应性
与反应: Mouse -
免疫原
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阳性对照
- Mouse kidney tissue lysate; Mouse kidney tissue, mouse kidney cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab124505于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF |
Use a concentration of 20 µg/ml.
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| WB | (1) |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 41 kDa.Can be blocked with Angiotensin II Type 1 Receptor peptide (ab176148).
|
| IHC-P |
Use a concentration of 2.5 µg/ml.
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| 说明 |
|---|
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ICC/IF
Use a concentration of 20 µg/ml. |
|
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 41 kDa.Can be blocked with Angiotensin II Type 1 Receptor peptide (ab176148). |
|
IHC-P
Use a concentration of 2.5 µg/ml. |
靶标
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功能
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. -
组织特异性
Liver, lung, adrenal and adrenocortical adenomas. -
疾病相关
Defects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
翻译后修饰
C-terminal Ser or Thr residues may be phosphorylated. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 11607 Mouse
- Entrez Gene: 11608 Mouse
- SwissProt: P29754 Mouse
- SwissProt: P29755 Mouse
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别名
- AG2S antibody
- Agtr 1 antibody
- Agtr1 antibody
see all
图片
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Western blot - Anti-Angiotensin II Type 1 Receptor antibody (ab124505)Lane 1 : Anti-Angiotensin II Type 1 Receptor antibody (ab124505) at 1 µg/ml
Lane 2 : Anti-Angiotensin II Type 1 Receptor antibody (ab124505) at 2 µg/ml
All lanes : Mouse kidney tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 41 kDa -
Immunocytochemistry/ Immunofluorescence - Anti-Angiotensin II Type 1 Receptor antibody (ab124505)Immunofluorescence of AGTR1 in mouse kidney cells using ab124505 at 20 ug/ml.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiotensin II Type 1 Receptor antibody (ab124505)Immunohistochemical analysis of mouse kidney tissue section labelling Angiotensin II Type 1 Receptor with ab124505, at 2.5 µg/ml.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiotensin II Type 1 Receptor antibody (ab124505)ab124505, at 2.5 µg/ml, staining Angiotensin II Type 1 Receptor in paraffin-embedded Mouse kidney tissue by Immunohistochemistry.
实验方案
数据表及文件
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Datasheet download
文献 (32)
ab124505 被引用在 32 文献中.
- Hirunpattarasilp C et al. SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction. Brain 146:727-738 (2023). PubMed: 35867861
- Ji J et al. Emodin attenuates diabetic kidney disease by inhibiting ferroptosis via upregulating Nrf2 expression. Aging (Albany NY) 15:7673-7688 (2023). PubMed: 37552124
- Qi J et al. Exercise Training Attenuates Hypertension via Suppressing ROS/MAPK/NF-κB/AT-1R Pathway in the Hypothalamic Paraventricular Nucleus. Nutrients 14:N/A (2022). PubMed: 36235619
- Li Y et al. Factors associated with the progression of mesangial lesions in IgA nephropathy: A comparative analysis of renal re-biopsies. Front Endocrinol (Lausanne) 13:1004289 (2022). PubMed: 36479219
- Wang Y et al. IgA Nephropathy with Macroproteinuria and a GFR of 20-30 ml/min/1.73 m2 May Still Benefit from RAS Inhibition. J Renin Angiotensin Aldosterone Syst 2022:9162427 (2022). PubMed: 36660420
