JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB224350

Anti-Amphiregulin抗体

Anti-Amphiregulin antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal Amphiregulin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AREG aa 1-200.

查看别名

AREGB, SDGF, AREG, Amphiregulin, AR, Colorectum cell-derived growth factor, CRDGF

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amphiregulin antibody (AB224350)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amphiregulin antibody (AB224350)

Paraffin-embedded human testis stained for Amphiregulin using ab224350 at 1/500 dilution in immunohistochemical analysis. Shows weak cytoplasmic and membranous positivity in cells in seminiferous ducts.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amphiregulin antibody (AB224350)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amphiregulin antibody (AB224350)

Paraffin-embedded human Fallopian tube stained for Amphiregulin using ab224350 at 1/500 dilution in immunohistochemical analysis. Shows moderate cytoplasmic and membranous positivity in glandular cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amphiregulin antibody (AB224350)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amphiregulin antibody (AB224350)

Paraffin-embedded human liver stained for Amphiregulin using ab224350 at 1/500 dilution in immunohistochemical analysis. Shows no positivity in hepatocytes cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amphiregulin antibody (AB224350)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amphiregulin antibody (AB224350)

Paraffin-embedded human placenta stained for Amphiregulin using ab224350 at 1/500 dilution in immunohistochemical analysis. Shows moderate cytoplasmic and membranous positivity in trophoblastic cells.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human AREG aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P15514

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

'Amphiregulin' also known as 'AREG' or 'Amphiregulin protein' is a member of the epidermal growth factor (EGF) family. It is a 252 amino acid protein with a predicted mass of approximately 27-29 kDa. Amphiregulin shows expression in various tissues including epithelial cells fibroblasts and immune cells. This protein functions as a ligand for the EGF receptor (EGFR) leading to receptor dimerization and subsequent activation of downstream signaling pathways.
Biological function summary

'Amphiregulin' plays a critical role in cell proliferation differentiation and tissue remodeling. It is not part of a constitutive complex but rather exerts its effects through interaction with EGFR a receptor tyrosine kinase. Amphiregulin contributes significantly to mammary gland development and has a notable role in wound healing. Beyond its developmental roles Amphiregulin can impact immune modulation and inflammation processes.

Pathways

'Amphiregulin' significantly contributes to the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) pathways. These pathways influence cell survival growth and proliferation. Amphiregulin interacts with EGFR and by extension has relationships with other EGFR ligands such as EGF and transforming growth factor-alpha (TGF-alpha). These pathways underline the importance of Amphiregulin in maintaining cellular functions and responding to external stimuli.

'Amphiregulin' has strong associations with cancer and asthma. Overexpression of Amphiregulin can lead to increased cancer cell proliferation and it has been implicated in diverse cancers such as breast and colorectal cancer. Additionally the protein plays a role in airway remodeling in asthma contributing to bronchial hyper-responsiveness. In these contexts Amphiregulin's interactions with EGFR are central influencing disease progression and response to treatment.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
See full target information AREG
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology :18676 PubMed37997936

2023

WITHDRAWN: Ethyl acetate extracted from the chinese medicinal plant Caesalpinia sappan L alleviates gustatory response in diabetes mellitus rats.

Applications

Unspecified application

Species

Unspecified reactive species

Xun Cao,Li Cui,Wen Yang

Journal of virology 93: PubMed31434729

2019

Transcriptional Response of Ovine Lung to Infection with Jaagsiekte Sheep Retrovirus.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Eleonora Karagianni,Deepali Vasoya,Jeanie Finlayson,Henny M Martineau,Ann R Wood,Chris Cousens,Mark P Dagleish,Mick Watson,David J Griffiths
View all publications
style
left-column
style
left-column
style
right-column

替代产品

Primary Antibodies

AB180722

Anti-Amphiregulin antibody

Western blot - Anti-Amphiregulin antibody (AB180722)

  • 4
  • 3
Primary Antibodies

AB194628

Anti-Amphiregulin antibody [7D17]

  • 0
  • 0
Primary Antibodies

AB89119

Anti-Amphiregulin antibody [MM0089-8K16]

Western blot - Anti-Amphiregulin antibody [MM0089-8K16] (AB89119)

  • 0
  • 0
Primary Antibodies

AB234750

Anti-Amphiregulin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amphiregulin antibody (AB234750)

  • 0
  • 0

搭配使用产品

Assay Kits

AB222504

Human Amphiregulin ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Amphiregulin ELISA Kit (AB222504)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB252634

Anti-GM-CSF antibody [EPR22272-71] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-GM-CSF antibody [EPR22272-71] - BSA and Azide free (Detector) (AB252634)

  • 0
  • 0
Primary Antibodies

AB134401

Anti-Fas Ligand antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fas Ligand antibody (AB134401)

  • 5
  • 2
Primary Antibodies

AB278327

Anti-CCL1 antibody [EPR24171-79] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-CCL1 antibody [EPR24171-79] - BSA and Azide free (Detector) (AB278327)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com