Anti-Alpha B Crystallin (phospho S45)抗体(ab5598)
Key features and details
- Rabbit polyclonal to Alpha B Crystallin (phospho S45)
- Suitable for: WB
- Reacts with: Recombinant fragment
- Isotype: IgG
概述
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产品名称
Anti-Alpha B Crystallin (phospho S45)抗体
参阅全部 Alpha B Crystallin 一抗 -
描述
兔多克隆抗体to Alpha B Crystallin (phospho S45) -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Recombinant fragment
预测可用于: Sheep, Rabbit, Hamster, Pig, Cynomolgus monkey
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免疫原
Synthetic peptide corresponding to Human Alpha B Crystallin aa 1-100 (phospho S45).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: 96% PBS, 3% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa.
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| 说明 |
|---|
|
WB
Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa. |
靶标
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功能
May contribute to the transparency and refractive index of the lens. -
组织特异性
Lens as well as other tissues. -
疾病相关
Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients. -
序列相似性
Belongs to the small heat shock protein (HSP20) family. -
细胞定位
Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. - Information by UniProt
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数据库链接
- Entrez Gene: 102128339 Cynomolgus monkey
- Entrez Gene: 100127443 Pig
- Entrez Gene: 100009295 Rabbit
- Entrez Gene: 497274 Sheep
- SwissProt: Q60HG8 Cynomolgus monkey
- SwissProt: Q7M2W6 Pig
- SwissProt: P41316 Rabbit
- SwissProt: Q5ENY9 Sheep
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别名
- AACRYA antibody
- Alpha B crystallin antibody
- Alpha crystallin B chain antibody
see all
图片
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Western blot - Anti-Alpha B Crystallin (phospho S45) antibody (ab5598)Western blot of recombinant bovine phospho-alpha-B crystallin (Ser45) using ab5598. Lane 1 is phospho-alpha-B crystallin (Ser45) and lane 2 is unphosphorylated alpha-B crystallin.
数据表及文件
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Datasheet download
文献 (3)
ab5598 被引用在 3 文献中.
- Muraleva NA et al. MEK1/2-ERK Pathway Alterations as a Therapeutic Target in Sporadic Alzheimer's Disease: A Study in Senescence-Accelerated OXYS Rats. Antioxidants (Basel) 10:N/A (2021). PubMed: 34208998
- Kuipers HF et al. Phosphorylation of aB-crystallin supports reactive astrogliosis in demyelination. Proc Natl Acad Sci U S A 114:E1745-E1754 (2017). PubMed: 28196893
- Tanito M et al. Diagnostic Western blot for lens-specific proteins in aqueous fluid after traumatic lens-induced uveitis. Jpn J Ophthalmol 53:436-9 (2009). PubMed: 19763765
