重组Anti-Alpha B Crystallin抗体[SP288] (ab226839)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)](https://www.abcam.cn/ps/products/226/ab226839/Images/ab226839-288349-ab226839A.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [SP288] to Alpha B Crystallin
- Suitable for: IHC-P
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-Alpha B Crystallin抗体[SP288]
参阅全部 Alpha B Crystallin 一抗 -
描述
兔单克隆抗体[SP288] to Alpha B Crystallin -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow, Pig
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免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- IHC-P: Human renal cell carcinoma, melanoma, kidney, cerebellum, spinal cord and heart tissues.
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常规说明
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
纯度
Protein A/G purified -
纯化说明
Purified from TCS by protein A/G. -
克隆
单克隆 -
克隆编号
SP288 -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab226839于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Primary incubation for 10 minutes at room temperature. |
| 说明 |
|---|
|
IHC-P
1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Primary incubation for 10 minutes at room temperature. |
靶标
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功能
May contribute to the transparency and refractive index of the lens. -
组织特异性
Lens as well as other tissues. -
疾病相关
Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients. -
序列相似性
Belongs to the small heat shock protein (HSP20) family. -
细胞定位
Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. - Information by UniProt
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数据库链接
- Entrez Gene: 281719 Cow
- Entrez Gene: 1410 Human
- Entrez Gene: 12955 Mouse
- Entrez Gene: 100127443 Pig
- Entrez Gene: 25420 Rat
- Omim: 123590 Human
- SwissProt: P02510 Cow
- SwissProt: P02511 Human
see all -
别名
- AACRYA antibody
- Alpha B crystallin antibody
- Alpha crystallin B chain antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)
Formalin-fixed, paraffin-embedded human renal cell carcinoma tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)](https://www.abcam.cn/ps/products/226/ab226839/Images/ab226839-288348-ab226839C.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)Formalin-fixed, paraffin-embedded human melanoma tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)](https://www.abcam.cn/ps/products/226/ab226839/Images/ab226839-288347-ab226839D.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)Formalin-fixed, paraffin-embedded human kidney tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)](https://www.abcam.cn/ps/products/226/ab226839/Images/ab226839-288346-ab226839E.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)Formalin-fixed, paraffin-embedded human cerebellum tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)](https://www.abcam.cn/ps/products/226/ab226839/Images/ab226839-288345-ab226839F.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)Formalin-fixed, paraffin-embedded human spinal cord tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)](https://www.abcam.cn/ps/products/226/ab226839/Images/ab226839-288344-ab226839G.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Alpha B Crystallin antibody [SP288] (ab226839)Formalin-fixed, paraffin-embedded human heart tissue stained for Alpha B Crystallin using ab226839 at 1/100 dilution in immunohistochemical analysis.
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![Anti-Alpha B Crystallin antibody [SP288] (ab226839)](https://www.abcam.cn/ps/products/226/ab226839/Images/ab226839-7-benefits-of-recombinant-antibodies.png)
Anti-Alpha B Crystallin antibody [SP288] (ab226839)
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab226839 被引用在 1 文献中.
- Ljungblad L et al. Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E2 and suppress tumor growth in medulloblastoma. Life Sci 295:120394 (2022). PubMed: 35157910