Anti-alpha A + alpha B Crystallin抗体(ab63998)
Key features and details
- Rabbit polyclonal to alpha A + alpha B Crystallin
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-alpha A + alpha B Crystallin抗体 -
描述
兔多克隆抗体to alpha A + alpha B Crystallin -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Full length protein corresponding to Alpha A + alpha B Crystallin. Bovine alpha/beta crystalin which has greater than 80% homology with human alpha/beta crystalin.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.02% Thimerosal (merthiolate)
Constituent: Whole serum -
Concentration information loading... -
纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab63998于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/1000 - 1/4000.
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| 说明 |
|---|
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IHC-P
1/1000 - 1/4000. |
靶标
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相关性
Crystallins are separated into two classes: taxon specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Alpha crystallins are composed of two gene products: alpha A and alpha B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. -
细胞定位
Cytoplasmic -
数据库链接
- Entrez Gene: 1409 Human
- Entrez Gene: 1410 Human
- Omim: 123580 Human
- Omim: 123590 Human
- SwissProt: P02489 Human
- SwissProt: P02511 Human
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别名
- Alpha crystallin A chain antibody
- Alpha crystallin B chain antibody
- CRYA1 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha A + alpha B Crystallin antibody (ab63998)Ab63998 (1:2000) staining of human brain tissue showing aß crystallin accumulation in Rosenthal fibres. Secondary antibody biotinylated Goat anti-rabbit (1/2000). (A) Shows the early stages of aß crystallin accumulation in astrocytes, (B) astrocyte begins to hypertrophy with aß crystallin accumulation, (C) the astrocyte begins to further hypertrophy and cell structure is lost.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab63998 尚未被引用在任何文献中。