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AB228541

Anti-alpha 1 Glycine Receptor/GLRA1 抗体

Anti-alpha 1 Glycine Receptor/GLRA1 antibody

1

(1 Review)

|

(2 Publications)

Rabbit Polyclonal alpha 1 Glycine Receptor/GLRA1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Rat samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GLRA1.

查看别名

Glycine receptor subunit alpha-1, Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit, GLRA1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha 1 Glycine Receptor/GLRA1 antibody (AB228541)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha 1 Glycine Receptor/GLRA1 antibody (AB228541)

Paraffin-embedded OVCA (human) xenograft tissue stained for alpha 1 Glycine Receptor/GLRA1 using ab228541 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-alpha 1 Glycine Receptor/GLRA1 antibody (AB228541)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-alpha 1 Glycine Receptor/GLRA1 antibody (AB228541)

4% paraformaldehyde-fixed DIV9 rat E18 primary cortical neuron cells labeling alpha 1 Glycine Receptor/GLRA1 using ab228541 at 1/500 dilution.

The nuclear counterstain is DAPI (blue). beta Tubulin is labeled with an anti-beta Tubulin antibody (red).

Western blot - Anti-alpha 1 Glycine Receptor/GLRA1 antibody (AB228541)
  • WB

Supplier Data

Western blot - Anti-alpha 1 Glycine Receptor/GLRA1 antibody (AB228541)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-alpha 1 Glycine Receptor/GLRA1 antibody (ab228541) at 1/1500 dilution

All lanes:

HeLa S3 whole cell lysate at 30 µg

Predicted band size: 53 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Rat, Human

应用

WB, ICC/IF, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human GLRA1. The exact immunogen used to generate this antibody is proprietary information.

P23415

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替代产品

Primary Antibodies

AB192508

Anti-alpha 1 Glycine Receptor/GLRA1 antibody

Western blot - Anti-alpha 1 Glycine Receptor/GLRA1 antibody (AB192508)

  • 0
  • 0
Primary Antibodies

AB166935

Anti-alpha 1 Glycine Receptor/GLRA1 antibody

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
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Primary Antibodies

AB302667

Anti-c-Fos antibody [N486/32]

BOND RX™ Validated|Recombinant|Lab Essentials|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Fos antibody [N486/32] (AB302667)

  • 0
  • 0
Primary Antibodies

AB97628

Anti-GLRA2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLRA2 antibody (AB97628)

  • 0
  • 0
Primary Antibodies

AB31232

Anti-Glutamate Receptor 1 (AMPA subtype) antibody

BOND RX™ Validated

Western blot - Anti-Glutamate Receptor 1 (AMPA subtype) antibody (AB31232)

  • 5
  • 9
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The alpha 1 Glycine Receptor also known as GLRA1 is a ligand-gated ion channel receptor. It plays an important role in transmitting inhibitory neurotransmission by binding glycine a neurotransmitter. The receptor possesses a mass around 48 kDa and is mainly expressed in the central nervous system particularly in the spinal cord and brainstem. This receptor helps regulate chloride ion influx which stabilizes neuronal membrane potential by reducing the likelihood of neuron firing.
Biological function summary

The GLRA1 facilitates inhibitory synapses in the central nervous system. Working as part of a larger receptor complex it couples with glycine to enable chloride anion flow across the neuronal membrane. This results in hyperpolarization which decreases the neuronal excitability. The receptor operates within a pentameric configuration often interacting with other subunits like beta glycine receptor subunits to form heteromeric channels.

Pathways

The GLRA1 is essential in the glycinergic pathway which serves to modulate excitatory signals in the nervous system by providing inhibitory control. It closely relates to other ligand-gated ion channels such as the GABAA receptor which shares a similar inhibitory function. The proper functioning of GLRA1 ensures balance in neurotransmission and prevents excessive neuronal firing which can lead to disorders.

Dysfunctional GLRA1 contributes to hyperekplexia also known as startle disease a genetic neurological disorder affecting muscle control. Mutations in the GLRA1 affect its ability to bind glycine effectively leading to impaired inhibitory neurotransmission. This receptor also shows a connection to disorders involving neurotransmission imbalance when linked with the protein gephyrin which anchors and clusters the glycine receptors at synaptic sites to ensure proper inhibitory signaling.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Subunit of heteromeric glycine-gated chloride channels (PubMed : 14551753, PubMed : 23994010, PubMed : 25730860, PubMed : 37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed : 8298642, PubMed : 9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed : 25445488). Channel activity is potentiated by ethanol (PubMed : 25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).
See full target information GLRA1
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eadw9952 PubMed40864703

2025

Mitochondrial ROS drive foam cell formation via STAT5 signaling in atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Laura Boccuni,Frieda Marka,Manuel Salzmann,Alessia Schirripa,Elisabeth Ableitner,Magdalena Siller,Mira Brekalo,Patrick Haider,Stefan Stojkovic,Christoph Neumayer,Tiit Örd,Karoline Kollmann,Alice Assinger,Thomas Decker,Thomas Köcher,Michael B Fischer,Marion Mußbacher,Andreas Bergthaler,Christian Hengstenberg,Bruno K Podesser,Minna U Kaikkonen,Johann Wojta,Philipp J Hohensinner

iScience 25:105366 PubMed36339258

2022

Single-cell RNA-seq transcriptomic landscape of human and mouse islets and pathological alterations of diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Kai Chen,Junqing Zhang,Youyuan Huang,Xiaodong Tian,Yinmo Yang,Aimei Dong
View all publications
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