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AB321352

Alexa Fluor® 750 Anti-SUCLA2 antibody [EPR14924]

Alexa Fluor® 750 Anti-SUCLA2 antibody [EPR14924]

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Rabbit Recombinant Monoclonal SUCLA2 antibody - conjugated to Alexa Fluor® 750.

查看别名

ATP-specific succinyl-CoA synthetase subunit beta, Succinyl-CoA synthetase beta-A chain, A-SCS, SCS-betaA, SUCLA2

不同偶联物与剂型 (10)

  • Unconjugated

    Anti-SUCLA2 antibody [EPR14924]

  • Carrier free

    Anti-SUCLA2 antibody [EPR14924] - BSA and Azide free

  • 578 PE

    PE Anti-SUCLA2 antibody [EPR14924]

  • 660 APC

    APC Anti-SUCLA2 antibody [EPR14924]

  • HRP

    HRP Anti-SUCLA2 antibody [EPR14924]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-SUCLA2 antibody [EPR14924]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-SUCLA2 antibody [EPR14924]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-SUCLA2 antibody [EPR14924]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-SUCLA2 antibody [EPR14924]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-SUCLA2 antibody [EPR14924]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR14924

亚型

IgG

偶联物

Alexa Fluor® 750

激发波长/发射波长

Ex: 749nm, Em: 775nm

不含载体蛋白

No

应用

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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我们推荐这个产品，因为它经常被用于相同的实验或相关的研究。

我们建议您务必查阅产品说明书，以确认其是否符合您的实验需求；若有疑问，也可联系我们的技术团队获取协助。

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产品详情

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

SUCLA2 also known as succinate-CoA ligase (ADP-forming) subunit beta is an enzyme with a molecular mass of approximately 48 kDa. It plays an important role in the mitochondrial matrix where it participates in the citric acid cycle. The enzyme is found in various tissues with higher expression in muscle and brain tissues. SUCLA2 functions as part of the succinyl-CoA synthetase complex which catalyzes the reversible conversion of succinyl-CoA to succinate with the concurrent substrate-level phosphorylation of GDP to GTP or ADP to ATP depending on tissue type.
Biological function summary

The SUCLA2 subunit is essential for energy metabolism. It forms a component of the succinyl-CoA synthetase complex working with the alpha subunit SUCLG1. This complex supports the provision of energy by converting GDP to GTP in processes needing high energy levels critical for maintaining cellular homeostasis. Therefore it especially supports tissues with high energy demands. The action of SUCLA2 links energy production with the metabolic pathways involved in cellular respiration.

Pathways

SUCLA2 plays a critical role in the citric acid cycle also known as the Krebs cycle. Part of this cycle SUCLA2 contributes to cellular respiration and energy production. The SUCLA2 protein closely interacts with SUCLG1 to form the functional succinyl-CoA synthetase enzyme. Additionally it shows connections to the electron transport chain where the products of its catalysis are used in ATP generation. Defects in these pathways can have widespread effects on cellular energy states and mitochondrial function.

SUCLA2 mutations are linked to mitochondrial DNA depletion syndromes particularly myopathy and encephalopathy. These conditions lead to severe energy metabolism impairments due to faulty mitochondrial function. SUCLA2 has also been associated with Leigh syndrome a neurodegenerative disorder marked by compromised cellular respiration. Such disorders point towards deficient ATP synthesis highlighting the interconnected role of SUCLA2 with other mitochondrial proteins involved in cellular energy metabolism.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed : 15877282). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity).
See full target information Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
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