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AB321132

Alexa Fluor® 750 Anti-Lamin B2 antibody [EPR9701(B)]

Alexa Fluor® 750 Anti-Lamin B2 antibody [EPR9701(B)]

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Rabbit Recombinant Monoclonal Lamin B2 antibody - conjugated to Alexa Fluor® 750.

查看别名

LMN2, LMNB2, Lamin-B2

不同偶联物与剂型 (10)

  • Unconjugated

    Anti-Lamin B2 antibody [EPR9701(B)]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Lamin B2 antibody [EPR9701(B)]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Lamin B2 antibody [EPR9701(B)]

  • Carrier free

    Anti-Lamin B2 antibody [EPR9701(B)] - BSA and Azide free

  • 578 PE

    PE Anti-Lamin B2 antibody [EPR9701(B)]

  • 660 APC

    APC Anti-Lamin B2 antibody [EPR9701(B)]

  • HRP

    HRP Anti-Lamin B2 antibody [EPR9701(B)]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Lamin B2 antibody [EPR9701(B)]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Lamin B2 antibody [EPR9701(B)]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-Lamin B2 antibody [EPR9701(B)]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR9701(B)

亚型

IgG

偶联物

Alexa Fluor® 750

激发波长/发射波长

Ex: 749nm, Em: 775nm

不含载体蛋白

No

应用

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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产品详情

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Lamin B2 also referred to as 'ln43' or 'lmnB2' is a lamin molecule with a molecular weight of approximately 66 kDa. It is an important component of the nuclear lamina an essential structure that provides mechanical support to the nuclear envelope. Lamin B2 is expressed in most cell types and is particularly abundant in cells with high proliferative capacity such as those in the fetal brain and liver. The protein is encoded by the LMNB2 gene and functions as an integral part of the nuclear envelope's architecture by interacting with other nuclear proteins.
Biological function summary

Lamin B2 plays a critical role in maintaining nuclear stability and chromatin organization. It is a part of a larger complex that includes Lamin B and other nuclear matrix proteins. This structural matrix is important for chromosomal segregation during cell division ensuring that the genetic material is evenly distributed between daughter cells. Lamin B2 also facilitates processes such as DNA replication and repair by serving as a scaffold for anchoring various molecular components within the nucleus.

Pathways

Lamin B2 is implicated in the regulation of the mitotic spindle formation during cell division which is a part of the cell cycle pathway. It interacts with proteins such as Lamin A and other nucleoporins contributing to the proper formation of nuclear pore complexes. Furthermore it plays a role in the pathway of apoptosis by modulating the release of factors from the nucleus that trigger cell death mechanisms. These interactions emphasize its importance in maintaining cellular function and integrity.

Alterations in Lamin B2 expression or function have been linked to certain types of cancer such as glioblastoma as well as to laminopathies. Laminopathies are a group of disorders caused by mutations in lamin proteins leading to defects in nuclear structure and function. Besides aberrant Lamin B2 is associated with neurological disorders through its interactions with other nuclear envelope protein components like Lamin A/C. These connections highlight the importance of Lamin B2 in both physiological processes and pathologies.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed : 33033404). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed : 33033404). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed : 33033404).
See full target information LMNB2
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