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AB321256

Alexa Fluor® 750 Anti-Involucrin antibody [EPR13054]

Alexa Fluor® 750 Anti-Involucrin antibody [EPR13054]

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Rabbit Recombinant Monoclonal Involucrin antibody - conjugated to Alexa Fluor® 750.

查看别名

Involucrin, IVL

不同偶联物与剂型 (10)

  • Unconjugated

    Anti-Involucrin antibody [EPR13054]

  • Carrier free

    Anti-Involucrin antibody [EPR13054] - BSA and Azide free

  • 578 PE

    PE Anti-Involucrin antibody [EPR13054]

  • 660 APC

    APC Anti-Involucrin antibody [EPR13054]

  • HRP

    HRP Anti-Involucrin antibody [EPR13054]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Involucrin antibody [EPR13054]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Involucrin antibody [EPR13054]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Involucrin antibody [EPR13054]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Involucrin antibody [EPR13054]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-Involucrin antibody [EPR13054]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR13054

亚型

IgG

偶联物

Alexa Fluor® 750

激发波长/发射波长

Ex: 749nm, Em: 775nm

不含载体蛋白

No

应用

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特异性

Unsuitable for rat IHC-P.

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产品详情

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性能和储存信息

形式
Liquid
纯度
Tissue culture supernatant
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Involucrin also known as involucrine envocrin or ivrn is a protein with a mass of approximately 68 kDa. You will find involucrin expressed mainly in the suprabasal layers of the stratified squamous epithelia including epidermis tongue and esophagus. This protein becomes cross-linked to form the cornified cell envelope (CCE) in the upper layers of the skin an essential structure for epidermal differentiation and maintenance of skin barrier function.
Biological function summary

Involucrin serves as a critical substrate in the formation of the CCE by providing reactive sites for cross-linking with other proteins like loricrin and small proline-rich proteins. This cross-linking process occurs due to the action of transglutaminases which bond glutamine residues of involucrin with lysine residues in other proteins reinforcing the skin's protective barrier. Involucrin is a part of the protein network integral to keratinocyte terminal differentiation playing a distinctive role in the formation of a resilient and impermeable skin surface.

Pathways

Involucrin contributes directly within the epidermal differentiation complex (EDC) supporting the skin barrier's structural stability and resilience. The protein prominently acts in the terminal differentiation pathway in conjunction with other structural proteins such as filaggrin and keratins. This pathway forms a protective barrier that resists mechanical stress and environmental insults functioning together to provide a robust defense against external factors.

Involucrin's role is highlighted in conditions like psoriasis and ichthyosis where skin barrier formation is disrupted. Aberrant expression or modification of involucrin can lead to compromised barrier integrity leading to these skin disorders. It relates closely to filaggrin in these conditions as both are essential for barrier function and mutations in these proteins can exacerbate skin pathologies. Understanding these connections helps us evaluate potential therapeutic strategies for skin barrier-related diseases.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
See full target information IVL
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