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AB321553

Alexa Fluor® 750 Anti-GATA4 antibody [EPR26718-103]

Alexa Fluor® 750 Anti-GATA4 antibody [EPR26718-103]

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Rabbit Recombinant Monoclonal GATA4 antibody - conjugated to Alexa Fluor® 750.

查看别名

Gata-4, Gata4, Transcription factor GATA-4, GATA-binding factor 4

不同偶联物与剂型 (8)

  • Unconjugated

    Anti-GATA4 antibody [EPR26718-103]

  • Carrier free

    Anti-GATA4 antibody [EPR26718-103] - BSA and Azide free

  • 578 PE

    PE Anti-GATA4 antibody [EPR26718-103]

  • 660 APC

    APC Anti-GATA4 antibody [EPR26718-103]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-GATA4 antibody [EPR26718-103]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-GATA4 antibody [EPR26718-103]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-GATA4 antibody [EPR26718-103]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-GATA4 antibody [EPR26718-103]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR26718-103

亚型

IgG

偶联物

Alexa Fluor® 750

激发波长/发射波长

Ex: 749nm, Em: 775nm

不含载体蛋白

No

应用

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特异性

Unsuitable: WB: Human IHC-FR: Mouse

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Human GATA4 ELISA Kit

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我们推荐这个产品，因为它经常被用于相同的实验或相关的研究。

我们建议您务必查阅产品说明书，以确认其是否符合您的实验需求；若有疑问，也可联系我们的技术团队获取协助。

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产品详情

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GATA4 also known as GATA-binding protein 4 is a transcription factor that plays a significant role in gene expression regulation. It weighs approximately 44 kDa. This protein expresses mainly in cells of the heart gonads and liver. GATA4 functions through binding to the GATA sequence on DNA regulating various genes. The protein is well known for its involvement in cardiac development and function.
Biological function summary

GATA4 interacts with other transcription factors and co-factors to regulate developmental processes. It often forms complexes with proteins such as NKX2-5 and TBX5 influencing the expression of cardiac-specific genes. These interactions lead to tissue-specific gene expression control important in the differentiation and functioning of heart cells. GATA4 is also involved in the regulation of genes responsible for cell growth and apoptosis contributing to tissue homeostasis.

Pathways

GATA4 is a notable component of cardiac development and cellular differentiation pathways. It plays an integral role in the Wnt signaling pathway influencing heart development through gene transcription modification. GATA4 also collaborates with proteins such as MEF2 and BMP2 coordinating cardiac muscle differentiation. These pathways highlight its pivotal role in proper cardiovascular formation and function.

GATA4 mutations and dysregulation have links to congenital heart defects such as atrial septal defect (ASD). This condition associates with altered gene expression during heart development leading to structural abnormalities. GATA4 also relates to conditions like hypertrophic cardiomyopathy where its interaction with proteins like MYH7 suggests a complex network influencing cardiac hypertrophy. Understanding these connections is essential for developing targeted therapeutic strategies.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed : 35182466). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed : 9584153). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity).
See full target information Gata4
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