AB321309

Alexa Fluor® 750 Anti-Dnmt3a antibody [EPR18455]

Recombinant
RabMAb
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Rabbit Recombinant Monoclonal Dnmt3a antibody - conjugated to Alexa Fluor® 750.

查看别名

DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, Cysteine methyltransferase DNMT3A, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A

不同偶联物与剂型 (10)

Unconjugated

Anti-Dnmt3a antibody [EPR18455]
Carrier free

Anti-Dnmt3a antibody [EPR18455] - BSA and Azide free
578 PE

PE Anti-Dnmt3a antibody [EPR18455]
660 APC

APC Anti-Dnmt3a antibody [EPR18455]
HRP

HRP Anti-Dnmt3a antibody [EPR18455]
519 Alexa Fluor® 488

Alexa Fluor® 488 Anti-Dnmt3a antibody [EPR18455]
665 Alexa Fluor® 647

Alexa Fluor® 647 Anti-Dnmt3a antibody [EPR18455]
617 Alexa Fluor® 594

Alexa Fluor® 594 Anti-Dnmt3a antibody [EPR18455]
565 Alexa Fluor® 555

Alexa Fluor® 555 Anti-Dnmt3a antibody [EPR18455]
603 Alexa Fluor® 568

Alexa Fluor® 568 Anti-Dnmt3a antibody [EPR18455]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR18455

亚型

IgG

偶联物

Alexa Fluor® 750

激发波长/发射波长

Ex: 749nm, Em: 775nm

不含载体蛋白

应用

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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为什么推荐这个？

我们推荐这个产品，因为它经常被用于相同的实验或相关的研究。

我们建议您务必查阅产品说明书，以确认其是否符合您的实验需求；若有疑问，也可联系我们的技术团队获取协助。

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产品详情

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle|Store in the dark

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed : 12138111, PubMed : 16357870, PubMed : 30478443). DNA methylation is coordinated with methylation of histones (PubMed : 12138111, PubMed : 16357870, PubMed : 30478443). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed : 12138111, PubMed : 16357870, PubMed : 30478443). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity).

See full target information DNMT3A

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Alexa Fluor® 750 Anti-Dnmt3a antibody [EPR18455]