Alexa Fluor® 750 Anti-DNA Polymerase beta antibody [EPR12722(B)]
Alexa Fluor® 750 Anti-DNA Polymerase beta antibody [EPR12722(B)]
- Recombinant
- RabMAb
- 了解详情
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Rabbit Recombinant Monoclonal DNA Polymerase beta antibody - conjugated to Alexa Fluor® 750.
查看别名
DNA polymerase beta, 5'-deoxyribose-phosphate lyase, AP lyase, 5'-dRP lyase, POLB
不同偶联物与剂型 (10)
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Anti-DNA Polymerase beta antibody [EPR12722(B)]
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Anti-DNA Polymerase beta antibody [EPR12722(B)] - BSA and Azide free
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578 PE
PE Anti-DNA Polymerase beta antibody [EPR12722(B)]
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660 APC
APC Anti-DNA Polymerase beta antibody [EPR12722(B)]
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HRP Anti-DNA Polymerase beta antibody [EPR12722(B)]
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519 Alexa Fluor® 488
Alexa Fluor® 488 Anti-DNA Polymerase beta antibody [EPR12722(B)]
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665 Alexa Fluor® 647
Alexa Fluor® 647 Anti-DNA Polymerase beta antibody [EPR12722(B)]
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617 Alexa Fluor® 594
Alexa Fluor® 594 Anti-DNA Polymerase beta antibody [EPR12722(B)]
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565 Alexa Fluor® 555
Alexa Fluor® 555 Anti-DNA Polymerase beta antibody [EPR12722(B)]
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603 Alexa Fluor® 568
Alexa Fluor® 568 Anti-DNA Polymerase beta antibody [EPR12722(B)]
产品详情
We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.
Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
性能和储存信息
形式
纯化工艺
存储溶液
运输条件
推荐的短期储存时间
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
DNA polymerase beta helps to maintain genome integrity by repairing DNA lesions caused by oxidation alkylation or deamination. This protein often collaborates with other components of the DNA repair pathways but it does not directly form a larger protein complex focusing instead on its important function in BER. When DNA damage like single-strand breaks occur pol β carries out important gap-filling synthesis steps preparing the strand for subsequent ligation.
Pathways
DNA polymerase beta functions critically in base excision repair and acts alongside other important proteins like XRCC1. The BER pathway operates to correct DNA damage from endogenous sources preventing harmful mutations. This pathway is essential for maintaining cellular stability and protecting cells from apoptosis or malignant transformation that might occur if DNA damage propagates.
产品实验方案
- Visit the General protocols
- Visit the Troubleshooting
靶点信息
Abcam Product Promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com