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重组RabMAb

重组Alexa Fluor® 750 Anti-beta Tubulin抗体[EPR1330] - Microtubule Marker (ab320895)

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Alexa Fluor® 750 Anti-beta Tubulin antibody [EPR1330] - Microtubule Marker (ab320895)

    Key features and details

    • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
    • Alexa Fluor® 750 Rabbit monoclonal [EPR1330] to beta Tubulin - Microtubule Marker
    • Suitable for: Target binding affinity, Antibody labelling
    • Conjugation: Alexa Fluor® 750. Ex: 749nm, Em: 775nm

    Conjugates logo Related conjugates and formulations

    Alexa Fluor® 488 Alexa Fluor® 555 Alexa Fluor® 594 Alexa Fluor® 647 APC Carrier Free HRP PE Unconjugated

    概述

    • 产品名称

      Alexa Fluor® 750 Anti-beta Tubulin抗体[EPR1330] - Microtubule Marker
      参阅全部 beta Tubulin 一抗

    • 描述

      Alexa Fluor® 750兔单克隆抗体[EPR1330] to beta Tubulin - Microtubule Marker

    • 宿主

      Rabbit

    • 偶联物

      Alexa Fluor® 750. Ex: 749nm, Em: 775nm

    • 经测试应用

      适用于: Target binding affinity, Antibody labellingmore details

    • 免疫原

      Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

    • 常规说明

      This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.

      For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program: learn more here.

      This product is a recombinant monoclonal antibody, which offers several advantages including:

      • - High batch-to-batch consistency and reproducibility
      • - Improved sensitivity and specificity
      • - Long-term security of supply
      • - Animal-free production
      For more information see here.

      Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

      Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

    性能

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab320895于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    Target binding affinity
    Use at an assay dependent concentration.
    Antibody labelling
    Use at an assay dependent concentration.
    说明
    Target binding affinity
    Use at an assay dependent concentration.
    Antibody labelling
    Use at an assay dependent concentration.

    靶标

    • 功能

      Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

    • 组织特异性

      Ubiquitously expressed with highest levels in spleen, thymus and immature brain.

    • 疾病相关

      Cortical dysplasia, complex, with other brain malformations 6
      Skin creases, congenital symmetric circumferential, 1

    • 序列相似性

      Belongs to the tubulin family.

    • 结构域

      The highly acidic C-terminal region may bind cations such as calcium.

    • 翻译后修饰

      Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).
      Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear.
      Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.

    • 细胞定位

      Cytoplasm, cytoskeleton.
    • Information by UniProt

    • 别名

      • Beta 4 tubulin antibody
      • Beta 5 tubulin antibody
      • beta Ib tubulin antibody
      • Beta1 tubulin antibody
      • Class I beta tubulin antibody
      • M40 antibody
      • MGC117247 antibody
      • MGC16435 antibody
      • OK/SW cl.56 antibody
      • OK/SWcl.56 antibody
      • TBB5_HUMAN antibody
      • TUBB 1 antibody
      • TUBB 2 antibody
      • TUBB 5 antibody
      • TUBB antibody
      • TUBB1 antibody
      • TUBB2 antibody
      • TUBB5 antibody
      • tubulin beta 1 chain antibody
      • Tubulin beta 2 chain antibody
      • tubulin beta 5 chain antibody
      • Tubulin beta chain antibody
      • Tubulin beta class I antibody
      • tubulin beta polypeptide antibody
      • Tubulin beta-5 chain antibody
      see all

    图片

    • Alexa Fluor® 750 Anti-beta Tubulin antibody [EPR1330] - Microtubule Marker (ab320895)
      Alexa Fluor® 750 Anti-beta Tubulin antibody [EPR1330] - Microtubule Marker (ab320895)

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (0)

    发表研究结果有使用 ab320895？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab320895 尚未被引用在任何文献中。

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