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AB312797

重组Alexa Fluor® 568荧光Anti-TROP2抗体[SP293] - C-terminal

Alexa Fluor® 568 Anti-TROP2 antibody [SP293] - C-terminal

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Rabbit Recombinant Monoclonal TROP2 antibody - conjugated to Alexa Fluor® 568.

查看别名

GA733-1, M1S1, TROP2, TACSTD2, Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1

不同偶联物与剂型 (11)

  • Unconjugated

    Anti-TROP2 antibody [SP293] - C-terminal

  • 578 PE

    PE Anti-TROP2 antibody [SP293] (C-terminal)

  • HRP

    HRP Anti-TROP2 antibody [SP293] (C-terminal)

  • Alkaline Phosphatase

    Alkaline Phosphatase Anti-TROP2 antibody [SP293] - C-terminal

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-TROP2 antibody [SP293] - C-terminal

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-TROP2 antibody [SP293] - C-terminal

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-TROP2 antibody [SP293] - C-terminal

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-TROP2 antibody [SP293] - C-terminal

  • 660 APC

    APC Anti-TROP2 antibody [SP293] (C-terminal)

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-TROP2 antibody [SP293] - C-terminal

  • Carrier free

    Anti-TROP2 antibody [SP293] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

SP293

亚型

IgG

偶联物

Alexa Fluor® 568

激发波长/发射波长

Ex: 578nm, Em: 603nm

不含载体蛋白

No

应用

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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为什么推荐这个？

我们推荐这个产品，因为它经常被用于相同的实验或相关的研究。

我们建议您务必查阅产品说明书，以确认其是否符合您的实验需求；若有疑问，也可联系我们的技术团队获取协助。

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产品详情

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TROP2 also known as TACSTD2 or tumor-associated calcium signal transducer 2 is a single-pass type I membrane glycoprotein. This protein is about 35 kDa in mass and primarily expresses in epithelial tissues. It acts as a transmembrane receptor that plays a role in signal transduction due to its domain structure binding and activation processes on the cell surface. TROP2 exhibits high expression in several types of tumors making it a potential target for therapeutic antibodies like anti-TROP2 anti trop2 or anti-TROP-2.
Biological function summary

TROP2 mediates calcium signaling and cell proliferation. It functions by being a part of a signaling complex on the cell membrane which affects multiple cellular activities such as cell growth motility and survival. Its role in maintaining the integrity of the epithelial cell layer also shows TROP2's significance in normal tissue homeostasis. The interaction of TROP2 with the extracellular matrix and other cell surface proteins support the structural integrity and communication between cells.

Pathways

TROP2 plays a central role in the PI3K/AKT and MAPK signaling pathways that regulate cell growth and survival. Within these pathways TROP2 works in concert with proteins like ERK and AKT important for transmitting extracellular signals into appropriate cellular responses. These pathways are key regulators of many physiological processes including cell cycle progression and apoptosis prevention.

TROP2 is strongly associated with several types of cancers particularly epithelial cancers like breast and pancreatic cancer. Overexpression of TROP2 in tumors often correlates with poor prognosis and aggressive disease phenotypes. Interaction between TROP2 and proteins like EGFR in cancer cell signaling pathways amplifies tumor progression and metastasis. Understanding these associations makes TROP2 a significant target in developing therapeutic strategies for cancer treatment.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

May function as a growth factor receptor.
See full target information TACSTD2
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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。
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关联产品

Select an associated product type
Alternative Version
Primary Antibodies

AB272014

Anti-TROP2 antibody [SP293] - BSA and Azide free

primary-antibodies

trop2-antibody-sp293-bsa-and-azide-free-ab272014

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(0 reviews)

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