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AB312679

重组Alexa Fluor® 568荧光Anti-SNRPD2抗体[EPR16762]

Alexa Fluor® 568 Anti-SNRPD2 antibody [EPR16762]

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Rabbit Recombinant Monoclonal SNRPD2 antibody - conjugated to Alexa Fluor® 568.

查看别名

SNRPD1, SNRPD2, Small nuclear ribonucleoprotein Sm D2, Sm-D2, snRNP core protein D2

不同偶联物与剂型 (10)

  • Unconjugated

    Anti-SNRPD2 antibody [EPR16762]

  • 578 PE

    PE Anti-SNRPD2 antibody [EPR16762]

  • 660 APC

    APC Anti-SNRPD2 antibody [EPR16762]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Sm-D2 antibody [EPR16762]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Sm-D2 antibody [EPR16762]

  • HRP

    HRP Anti-SNRPD2 antibody [EPR16762]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Sm-D2 antibody [EPR16762]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Sm-D2 antibody [EPR16762]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-SNRPD2 antibody [EPR16762]

  • Carrier free

    Anti-SNRPD2 antibody [EPR16762] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR16762

亚型

IgG

偶联物

Alexa Fluor® 568

激发波长/发射波长

Ex: 578nm, Em: 603nm

不含载体蛋白

No

应用

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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产品详情

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The small nuclear ribonucleoprotein D2 (SNRPD2) also known as Sm-D2 is a component of the spliceosomal small nuclear ribonucleoproteins (snRNP) essential for pre-mRNA splicing. It has a molecular weight of approximately 14 kDa and is ubiquitously expressed in various tissues highlighting its significant function across different cell types. SNRPD2 is part of the Sm protein family which plays an important role in the assembly and function of spliceosomal snRNPs.
Biological function summary

SNRPD2 participates in the formation of the spliceosomal core necessary for the removal of introns from pre-mRNA which is important for generating mature mRNA transcripts. This protein is a part of the spliceosome complex consisting of other snRNPs and numerous accessory proteins. SNRPD2's involvement in mRNA processing highlights its fundamental role in gene expression regulation affecting how cells translate genetic information into functional proteins.

Pathways

SNRPD2 is a critical element in the spliceosome pathway a major route for the post-transcriptional modification of RNA. This pathway is integral to the regulation of alternative splicing events influencing protein diversity. SNRPD2 also interacts with other spliceosomal proteins such as SNRPB and SNRPE cooperating to facilitate precise exon-exon junctions. The fidelity of this pathway depends substantially on the integrity and functionality of SNRPD2 alongside its protein partners.

SNRPD2 shows a connection to autoimmune conditions such as systemic lupus erythematosus (SLE) where autoantibodies target snRNP components including SNRPD2. This autoimmune disorder may disrupt normal spliceosomal function contributing to disease pathology. Additionally alterations in splicing pathways involving SNRPD2 have links to certain cancers where dysregulated splicing can lead to oncogenic transformations. Understanding SNRPD2's role in these conditions may reveal therapeutic targets for modulating splicing in disease contexts.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed : 11991638, PubMed : 18984161, PubMed : 19325628, PubMed : 23333303, PubMed : 25555158, PubMed : 26912367, PubMed : 28076346, PubMed : 28502770, PubMed : 28781166, PubMed : 32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed : 11991638, PubMed : 28076346, PubMed : 28502770, PubMed : 28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed : 15146077).
See full target information SNRPD2
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详情请参阅我们的条款与条件。
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关联产品

Select an associated product type
Alternative Version
Primary Antibodies

AB251254

Anti-SNRPD2 antibody [EPR16762] - BSA and Azide free

primary-antibodies

snrpd2-antibody-epr16762-bsa-and-azide-free-ab251254

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