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AB313043

重组Alexa Fluor® 568荧光Anti-PHOX2B抗体[EPR14423] - C-terminal

Alexa Fluor® 568 Anti-PHOX2B antibody [EPR14423] - C-terminal

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Rabbit Recombinant Monoclonal PHOX2B antibody - conjugated to Alexa Fluor® 568.

查看别名

PMX2B, PHOX2B, Paired mesoderm homeobox protein 2B, Neuroblastoma Phox, PHOX2B homeodomain protein, Paired-like homeobox 2B, NBPhox

不同偶联物与剂型 (7)

  • Carrier free

    Anti-PHOX2B antibody [EPR14423] - BSA and Azide free

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-PHOX2B antibody [EPR14423] - C-terminal

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-PHOX2B antibody [EPR14423] - C-terminal

  • Unconjugated

    Anti-PHOX2B antibody [EPR14423] - C-terminal

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-PHOX2B antibody [EPR14423] - C-terminal

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-PHOX2B antibody [EPR14423] - C-terminal

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-PHOX2B antibody [EPR14423] - C-terminal

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR14423

亚型

IgG

偶联物

Alexa Fluor® 568

激发波长/发射波长

Ex: 578nm, Em: 603nm

不含载体蛋白

No

应用

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特异性

The mouse recommendation is based on the WB results. We do not guarantee IHC-P for mouse.

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产品详情

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

PHOX2B also known as Paired-like Homeobox 2B is a transcription factor that plays a significant role in neural development. It is encoded by the PHOX2B gene and has a molecular weight of approximately 31 kDa. This protein is highly expressed in the central and peripheral nervous systems where it influences the differentiation and function of neural crest-derived cells. PHOX2B is particularly active in the brainstem regions that control vital autonomic functions.
Biological function summary

PHOX2B influences the development of noradrenergic neurons and parasympathetic ganglia. It often functions as part of a transcription factor complex interacting with other proteins to drive the expression of genes required for the autonomic nervous system. The control PHOX2B exerts over neuronal differentiation makes it essential for maintaining the proper functioning of neurons responsible for involuntary bodily processes.

Pathways

PHOX2B is integral to the development and maintenance of the autonomic nervous and respiratory systems. It interacts closely with RET a receptor tyrosine kinase within the neurotrophic signaling pathways that regulate neuronal growth and survival. Additionally the protein plays a role in the endothelin signaling pathway further demonstrating its importance in neurodevelopment.

Alterations in PHOX2B have been linked to disorders such as congenital central hypoventilation syndrome (CCHS) and neuroblastoma. CCHS results from mutations in the PHOX2B gene affecting respiratory control. In the context of cancer PHOX2B neuroblastoma pertains to its potential role in tumor formation alongside MYCN amplification which is a common alteration in neuroblastoma. Understanding PHOX2B’s interactions provides insights into its potential as a target for therapeutic interventions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.
See full target information PHOX2B
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