JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB312690

重组Alexa Fluor® 568荧光Anti-LIMPII抗体[EPR12080]

Alexa Fluor® 568 Anti-LIMPII antibody [EPR12080]

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Recombinant Monoclonal LIMPII antibody - conjugated to Alexa Fluor® 568.

查看别名

CD36, CD36L2, LIMP2, LIMPII, SCARB2, Lysosome membrane protein 2, 85 kDa lysosomal membrane sialoglycoprotein, CD36 antigen-like 2, Lysosome membrane protein II, Scavenger receptor class B member 2, LGP85, LIMP II

不同偶联物与剂型 (10)

  • Unconjugated

    Anti-LIMPII antibody [EPR12080]

  • 578 PE

    PE Anti-LIMPII antibody [EPR12080]

  • 660 APC

    APC Anti-LIMPII antibody [EPR12080]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-LIMPII antibody [EPR12080]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-LIMPII antibody [EPR12080]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-LIMPII antibody [EPR12080]

  • HRP

    HRP Anti-LIMPII antibody [EPR12080]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-LIMPII antibody [EPR12080]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-LIMPII antibody [EPR12080]

  • Carrier free

    Anti-LIMPII antibody [EPR12080] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR12080

亚型

IgG

偶联物

Alexa Fluor® 568

激发波长/发射波长

Ex: 578nm, Em: 603nm

不含载体蛋白

No

应用

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

style
left-column
style
left-column

产品详情

style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

LIMPII also known as LIMP-2 is a lysosomal membrane protein involved in the transport and degradation processes within cells. It has an approximate molecular mass of 54 kDa. LIMPII is mainly expressed in the lysosomal membranes of a variety of tissues notably in the kidney liver and spleen. Its structural characteristics enable it to function effectively within these cellular organelles delivering enzymes and other molecules essential for cellular maintenance and function.
Biological function summary

The protein plays a critical role in lipid and protein degradation and helps maintain cellular homeostasis. As part of the lysosomal membrane LIMPII facilitates the uptake and processing of large biomolecules into the lysosome. It functions as a receptor for the uptake of β-glucocerebrosidase forming a complex to assist in its proper delivery from the endoplasmic reticulum to the lysosomes. This receptor-ligand relationship ensures efficient enzymatic activity necessary for lipid metabolism.

Pathways

One finds that LIMPII participates in the sphingolipid metabolism pathway and is vital for glucosylceramide catabolism. It interacts with glucocerebrosidase in this pathway which plays a significant role in the metabolism of glycosphingolipids. Another pathway where LIMPII has importance is the autophagy pathway where it contributes to the fusion of autophagosomes with lysosomes. Its activity supports the turnover of cellular components maintaining cellular metabolic balance.

LIMPII's dysfunction has links to Gaucher's disease and atherosclerosis. Both conditions relate to improper lipid metabolism. In Gaucher's disease the interaction between LIMPII and glucocerebrosidase becomes disrupted leading to lysosomal storage issues. In contrast altered expressions of LIMPII correlate with atherosclerosis possibly due to its role in lipid processing. These associations suggest that LIMPII could be a significant factor in therapeutic approaches for these diseases.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting.. (Microbial infection) Acts as a receptor for enterovirus 71.
See full target information SCARB2
style
left-column
style
left-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。
style
left-column
style
right-column

关联产品

Select an associated product type
Alternative Version
Primary Antibodies

AB240186

Anti-LIMPII antibody [EPR12080] - BSA and Azide free

primary-antibodies

limpii-antibody-epr12080-bsa-and-azide-free-ab240186

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com