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AB312614

重组Alexa Fluor® 568荧光Anti-IQGAP1抗体[EPR5220]

Alexa Fluor® 568 Anti-IQGAP1 antibody [EPR5220]

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Rabbit Recombinant Monoclonal IQGAP1 antibody - conjugated to Alexa Fluor® 568.

查看别名

KIAA0051, IQGAP1, Ras GTPase-activating-like protein IQGAP1, p195

不同偶联物与剂型 (8)

  • Unconjugated

    Anti-IQGAP1 antibody [EPR5220]

  • 578 PE

    PE Anti-IQGAP1 antibody [EPR5220]

  • 660 APC

    APC Anti-IQGAP1 antibody [EPR5220]

  • HRP

    HRP Anti-IQGAP1 antibody [EPR5220]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-IQGAP1 antibody [EPR5220]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-IQGAP1 antibody [EPR5220]

  • Carrier free

    Anti-IQGAP1 antibody [EPR5220] - BSA and Azide free

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-IQGAP1 antibody [EPR5220]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR5220

亚型

IgG

偶联物

Alexa Fluor® 568

激发波长/发射波长

Ex: 578nm, Em: 603nm

不含载体蛋白

No

应用

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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产品详情

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

IQGAP1 also known as IQ motif containing GTPase activating protein 1 acts as a scaffold protein that interacts with several signaling molecules. It weighs approximately 189 kDa. This protein is expressed in various tissues but shows high expression in the brain liver and kidney. IQGAP1 contains multiple domains including four IQ motifs that bind to calmodulin and a Rho GTPase-activating protein-related domain that mediates interactions with GTPases.
Biological function summary

IQGAP1 plays a critical role in cytoskeletal organization cell adhesion and intracellular signaling. It participates in the formation of multiprotein complexes facilitating communication and structural integrity within the cell. IQGAP1 stabilizes the actin cytoskeleton and affects cell motility and polarity. It interacts with proteins such as E-cadherin and beta-catenin affecting cell-cell adhesion and signal transduction.

Pathways

IQGAP1 integrates signals from different pathways including the MAPK/ERK and Wnt pathways. It modulates the MAPK pathway by interacting with Raf and MEK kinases impacting cell proliferation and differentiation. In the Wnt signaling pathway IQGAP1 binds to APC and beta-catenin regulating gene transcription related to cell growth and division. These interactions highlight its role in coordinating cellular responses to various external signals.

IQGAP1 has associations with cancer and neurological disorders. In cancer alterations in IQGAP1 expression or function can lead to abnormal cell growth and metastasis due to disrupted signaling pathways like MAPK. Mutations and dysregulation of proteins such as Ras and beta-catenin commonly interact with IQGAP1 in oncogenic contexts. In neurological disorders its interaction with the actin cytoskeleton and signaling proteins can affect synapse formation and function with links to conditions such as schizophrenia and Alzheimer's disease.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed : 15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed : 20883816).
See full target information IQGAP1
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详情请参阅我们的条款与条件。
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关联产品

Select an associated product type
Alternative Version
Primary Antibodies

AB271893

Anti-IQGAP1 antibody [EPR5220] - BSA and Azide free

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Alternative Version
Primary Antibodies

AB222390

Anti-IQGAP1 antibody [EPR5220] - Low endotoxin, Azide free

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