AB312365

重组Alexa Fluor® 568荧光Anti-Indoleamine 2，3-dioxygenase抗体[SP260] - C-terminal

Alexa Fluor® 568 Anti-Indoleamine 2, 3-dioxygenase antibody [SP260] - C-terminal

RabMAb
Recombinant
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Rabbit Recombinant Monoclonal Indoleamine 2, 3-dioxygenase antibody - conjugated to Alexa Fluor® 568.

查看别名

IDO, INDO, IDO1, IDO-1

不同偶联物与剂型 (8)

519 Alexa Fluor® 488

Alexa Fluor® 488 Anti-Indoleamine 2, 3-dioxygenase antibody [SP260]
665 Alexa Fluor® 647

Alexa Fluor® 647 Anti-Indoleamine 2, 3-dioxygenase antibody [SP260] - C-terminal
578 PE

PE Anti-Indoleamine 2, 3-dioxygenase antibody [SP260] (C-terminal)
660 APC

APC Anti-Indoleamine 2, 3-dioxygenase antibody [SP260] (C-terminal)
HRP

HRP Anti-Indoleamine 2, 3-dioxygenase antibody [SP260] (C-terminal)
617 Alexa Fluor® 594

Alexa Fluor® 594 Anti-Indoleamine 2, 3-dioxygenase antibody [SP260] - C-terminal
565 Alexa Fluor® 555

Alexa Fluor® 555 Anti-Indoleamine 2, 3-dioxygenase antibody [SP260] - C-terminal
775 Alexa Fluor® 750

Alexa Fluor® 750 Anti-Indoleamine 2, 3-dioxygenase antibody [SP260] - C-terminal

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

SP260

亚型

IgG

偶联物

Alexa Fluor® 568

激发波长/发射波长

Ex: 578nm, Em: 603nm

不含载体蛋白

应用

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle|Store in the dark

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Indoleamine 2 3-dioxygenase (IDO) also known as IDO1 is an enzyme involved in the catabolism of tryptophan to kynurenine. It weighs approximately 45 kDa and it is an important target in immunoregulatory processes. IDO is highly expressed in antigen-presenting cells such as dendritic cells and macrophages as well as in various tumor cells where it helps modulate immune responses. This enzyme can also be measured by using assays like IDO ELISA.

Biological function summary

IDO plays a role in immune response regulation by degrading tryptophan an essential amino acid needed for T-cell proliferation. The depletion of tryptophan and the accumulation of its metabolites such as kynurenine cause immunosuppressive effects within the tissue microenvironment. While IDO functions mostly as a standalone enzyme its activity influences the cellular surroundings by altering the balance of local immune reactions.

Pathways

IDO integrates into the tryptophan metabolism pathway and is important in the kynurenine pathway. Through this pathway it maintains immune homeostasis and cell defense mechanisms. Proteins like kynureninase and kynurenine 3-monooxygenase also participate in the same metabolic processes which further extend the effects of tryptophan metabolism on immune cell behavior.

IDO is linked with cancer and chronic inflammatory conditions. In cancer elevated IDO expression suppresses anti-tumor immunity aiding tumor cells to evade immune surveillance. It also plays a role in autoimmune disorders by regulating excessive immune activity. During cancer progression IDO often works in conjunction with immune checkpoint proteins like PD-L1 which further enhances its immunosuppressive capabilities within the tumor microenvironment.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed : 17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed : 25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed : 25691885). Acts as a suppressor of anti-tumor immunity (PubMed : 14502282, PubMed : 23103127, PubMed : 25157255, PubMed : 25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed : 25691885). Protects the fetus from maternal immune rejection (PubMed : 25691885).

See full target information IDO1

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重组Alexa Fluor® 568荧光Anti-Indoleamine 2，3-dioxygenase抗体[SP260] - C-terminal