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AB312943

重组Alexa Fluor® 568荧光Anti-Collagen I抗体[EPR24331-53]

Alexa Fluor® 568 Anti-Collagen I antibody [EPR24331-53]

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Rabbit Recombinant Monoclonal COL1A1 antibody - conjugated to Alexa Fluor® 568.

查看别名

Cola1, Col1a1, Collagen alpha-1(I) chain, Alpha-1 type I collagen

不同偶联物与剂型 (9)

  • Unconjugated

    Anti-Collagen I antibody [EPR24331-53]

  • Carrier free

    Anti-Collagen I antibody [EPR24331-53] - BSA and Azide free

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Collagen I antibody [EPR24331-53]

  • 660 APC

    APC Anti-Collagen I antibody [EPR24331-53]

  • 578 PE

    PE Anti-Collagen I antibody [EPR24331-53]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Collagen I antibody [EPR24331-53]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Collagen I antibody [EPR24331-53]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Collagen I antibody [EPR24331-53]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Collagen I antibody [EPR24331-53]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR24331-53

亚型

IgG

偶联物

Alexa Fluor® 568

激发波长/发射波长

Ex: 578nm, Em: 603nm

不含载体蛋白

No

应用

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Total Collagen Assay Kit (Perchlorate-Free)

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为什么推荐这个？

我们推荐这个产品，因为它经常被用于相同的实验或相关的研究。

我们建议您务必查阅产品说明书，以确认其是否符合您的实验需求；若有疑问，也可联系我们的技术团队获取协助。

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产品详情

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Collagen type I also called collagen I is a structural protein expressed mainly in connective tissues such as skin tendon bone and ligaments. It serves as an important component in providing mechanical strength and integrity to these tissues. Collagen I is a fibrillar collagen known for its triple-helix structure composed of two alpha-1 chains and one alpha-2 chain and has a molecular mass of approximately 300 kDa. Researchers often employ collagen western blot and collagen ELISA techniques for its detection. Collagen suppliers offer various collagen antibodies used in these assays to study its distribution and function.
Biological function summary

Collagen type I plays a central role in maintaining the extracellular matrix and supporting cellular environments. It interacts with other matrix proteins and cells forming complexes that help in tissue development and repair. Type I collagen is especially important in bone matrix working alongside minerals like hydroxyapatite to provide rigidity and support. Anti-collagen antibodies aid in studying its biological functions and interactions which are critical to understanding tissue dynamics.

Pathways

Collagen type I interacts with multiple signaling cascades involved in tissue remodeling and repair. It is a significant player in the TGF-β pathway which regulates fibrosis and wound healing processes. In these pathways proteins such as fibronectin and integrins work in concert with collagen type I to orchestrate cellular responses to damage. Researchers often examine its role in these pathways to uncover therapeutic possibilities for disease interventions.

Collagen type I has strong connections to conditions like osteogenesis imperfecta and fibrosis. Mutations or irregularities in collagen I production can lead to osteogenesis imperfecta a genetic disorder characterized by brittle bones. In fibrosis excessive collagen deposition disrupts normal tissue architecture contributing to organ dysfunction. In both conditions type I collagen interacts with other proteins like matrix metalloproteinases which modulate its breakdown and remodeling highlighting its importance in disease pathology.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Type I collagen is a member of group I collagen (fibrillar forming collagen).
See full target information Col1a1
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详情请参阅我们的条款与条件。
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