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AB312611

重组Alexa Fluor® 568荧光Anti-Anterior Gradient 2抗体[EPR3278]

Alexa Fluor® 568 Anti-Anterior Gradient 2 antibody [EPR3278]

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Rabbit Recombinant Monoclonal Anterior Gradient 2 antibody - conjugated to Alexa Fluor® 568.

查看别名

AG2, UNQ515/PRO1030, AGR2, Anterior gradient protein 2 homolog, AG-2, hAG-2, HPC8, Secreted cement gland protein XAG-2 homolog

不同偶联物与剂型 (9)

  • Unconjugated

    Anti-Anterior Gradient 2 antibody [EPR3278]

  • 660 APC

    APC Anti-Anterior Gradient 2 antibody [EPR3278]

  • HRP

    HRP Anti-Anterior Gradient 2 antibody [EPR3278]

  • 578 PE

    PE Anti-Anterior Gradient 2 antibody [EPR3278]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Anterior Gradient 2 antibody [EPR3278]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Anterior Gradient 2 antibody [EPR3278]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Anterior Gradient 2 antibody [EPR3278]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Anterior Gradient 2 antibody [EPR3278]

  • Carrier free

    Anti-Anterior Gradient 2 antibody [EPR3278] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR3278

亚型

IgG

偶联物

Alexa Fluor® 568

激发波长/发射波长

Ex: 578nm, Em: 603nm

不含载体蛋白

No

应用

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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产品详情

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Anterior Gradient 2 (AG2) also known as AGR2 is a protein with a molecular weight of approximately 20 kDa. This protein is a member of the protein disulfide isomerase family and has an important mechanical role in facilitating protein folding within the endoplasmic reticulum. The protein exists mainly in epithelial tissues and notably in the gastrointestinal tract with high expression also found in the pancreas and lungs. AG2 is characterized by its interaction with various client proteins assisting in their proper folding and stability.
Biological function summary

The anterior gradient protein influences cellular processes such as proliferation and differentiation often playing a role in cellular adhesion and migration. This protein does not work alone but instead can form complexes with other molecules enhancing its functional capabilities. Such interactions highlight its significance in maintaining normal cell physiology and response to external stimuli.

Pathways

Anterior gradient protein participates in key signaling pathways including the Wnt signaling pathway and the unfolded protein response (UPR). Through these pathways AG2 associates with proteins like β-catenin influencing gene transcription and cellular outcomes. In the UPR its role is important in managing cellular stress and maintaining homeostasis by regulating protein folding and quality control mechanisms.

Anterior gradient protein shows strong associations with cancer particularly in tumors such as breast and lung cancer where it is often overexpressed. Its involvement links closely with proteins like MUC1 which is found in tumors suggesting a role in promoting cancer progression and metastasis. Additionally AG2 can be related to inflammatory bowel diseases where its dysregulation may result in epithelial barrier dysfunction and contribute to the pathology.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed : 23274113).
See full target information AGR2
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详情请参阅我们的条款与条件。
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关联产品

Select an associated product type
Alternative Version
Primary Antibodies

AB181829

Anti-Anterior Gradient 2 antibody [EPR3278] - BSA and Azide free

primary-antibodies

anterior-gradient-2-antibody-epr3278-bsa-and-azide-free-ab181829

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