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重组RabMAb

重组Alexa Fluor® 555荧光Anti-Retinoid X Receptor alpha/RXRA抗体[EPR7106] (ab318052)

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Alexa Fluor® 555 Anti-Retinoid X Receptor alpha/RXRA antibody [EPR7106] (ab318052)

    Key features and details

    • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
    • Alexa Fluor® 555 Rabbit monoclonal [EPR7106] to Retinoid X Receptor alpha/RXRA
    • Suitable for: Target binding affinity, Antibody labelling
    • Conjugation: Alexa Fluor® 555. Ex: 555nm, Em: 565nm

    Conjugates logo Related conjugates and formulations

    Carrier Free Unconjugated

    概述

    • 产品名称

      Alexa Fluor® 555荧光Anti-Retinoid X Receptor alpha/RXRA抗体[EPR7106]
      参阅全部 Retinoid X Receptor alpha/RXRA 一抗

    • 描述

      Alexa Fluor® 555荧光兔单克隆抗体[EPR7106] to Retinoid X Receptor alpha/RXRA

    • 宿主

      Rabbit

    • 偶联物

      Alexa Fluor® 555. Ex: 555nm, Em: 565nm

    • 经测试应用

      适用于: Target binding affinity, Antibody labellingmore details

    • 免疫原

      Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

    • 常规说明

      This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.

      For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for Abtrial: learn more here.

      This product is a recombinant monoclonal antibody, which offers several advantages including:

      • - High batch-to-batch consistency and reproducibility
      • - Improved sensitivity and specificity
      • - Long-term security of supply
      • - Animal-free production
      For more information see here.

      Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

      Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

    性能

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab318052于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    Target binding affinity
    Use at an assay dependent concentration.
    Antibody labelling
    Use at an assay dependent concentration.
    说明
    Target binding affinity
    Use at an assay dependent concentration.
    Antibody labelling
    Use at an assay dependent concentration.

    靶标

    • 功能

      Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

    • 组织特异性

      Highly expressed in liver, also found in lung, kidney and heart.

    • 序列相似性

      Belongs to the nuclear hormone receptor family. NR2 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.

    • 结构域

      Composed of three domains: a modulating N-terminal domain (AF1 domain), a DNA-binding domain and a C-terminal ligand-binding domain (AF2 domain).

    • 翻译后修饰

      Phosphorylated on serine and threonine residues mainly in the N-terminal modulating domain. Constiutively phosphorylated on Ser-21 in the presence or absence of ligand. Under stress conditions, hyperphosphorylated by activated JNK on Ser-56, Ser-70, Thr-82 and Ser-260 (By similarity). Phosphorylated on Ser-27, in vitro, by PKA. This phosphorylation is required for repression of cAMP-mediated transcriptional activity of RARA.
      Sumoylation negatively regulates transcriptional activity. Desumoylated specifically by SENP6.

    • 细胞定位

      Nucleus.
    • Information by UniProt

    • 别名

      • FLJ00280 antibody
      • FLJ00318 antibody
      • FLJ16020 antibody
      • FLJ16733 antibody
      • MGC102720 antibody
      • NR2B1 antibody
      • Nuclear receptor subfamily 2 group B member 1 antibody
      • OTTHUMP00000022510 antibody
      • Retinoic acid receptor RXR alpha antibody
      • Retinoic acid receptor RXR-alpha antibody
      • Retinoid X nuclear receptor alpha antibody
      • Retinoid X receptor alpha antibody
      • RXR alpha1 antibody
      • Rxra antibody
      • RXRA_HUMAN antibody
      • RXRalpha1 antibody
      see all

    图片

    • Alexa Fluor® 555 Anti-Retinoid X Receptor alpha/RXRA antibody [EPR7106] (ab318052)
      Alexa Fluor® 555 Anti-Retinoid X Receptor alpha/RXRA antibody [EPR7106] (ab318052)

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (0)

    发表研究结果有使用 ab318052？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab318052 尚未被引用在任何文献中。

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