AB312055

重组Alexa Fluor® 555荧光Anti-Aspartate Aminotransferase + FABP-1抗体[EPR12145]

Alexa Fluor® 555 Anti-Aspartate Aminotransferase + FABP-1 antibody [EPR12145]

RabMAb
Recombinant
了解详情

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Rabbit Recombinant Monoclonal FABP-1 antibody - conjugated to Alexa Fluor® 555.

查看别名

KYAT4, GOT2, mAspAT, Fatty acid-binding protein, Glutamate oxaloacetate transaminase 2, Kynurenine aminotransferase 4, Kynurenine aminotransferase IV, Kynurenine--oxoglutarate transaminase 4, Kynurenine--oxoglutarate transaminase IV, Plasma membrane-associated fatty acid-binding protein, Transaminase A, FABP-1, FABPpm

不同偶联物与剂型 (8)

665 Alexa Fluor® 647

Alexa Fluor® 647 Anti-Aspartate Aminotransferase + FABP-1 antibody [EPR12145]
HRP

HRP Anti-Aspartate Aminotransferase + FABP-1 antibody [EPR12145]
578 PE

PE Anti-Aspartate Aminotransferase +FABP-1 antibody [EPR12145]
660 APC

APC Anti-Aspartate Aminotransferase + FABP-1 antibody [EPR12145]
519 Alexa Fluor® 488

Alexa Fluor® 488 Anti-Aspartate Aminotransferase + FABP-1 antibody [EPR12145]
617 Alexa Fluor® 594

Alexa Fluor® 594 Anti-Aspartate Aminotransferase + FABP-1 antibody [EPR12145]
603 Alexa Fluor® 568

Alexa Fluor® 568 Anti-Aspartate Aminotransferase + FABP-1 antibody [EPR12145]
775 Alexa Fluor® 750

Alexa Fluor® 750 Anti-Aspartate Aminotransferase + FABP-1 antibody [EPR12145]

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR12145

亚型

IgG

偶联物

Alexa Fluor® 555

激发波长/发射波长

Ex: 555nm, Em: 565nm

不含载体蛋白

应用

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特异性

The mouse and rat recommendation is based on the WB results. We do not guarantee IHC-P for mouse and rat.

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产品详情

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle|Store in the dark

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Aspartate Aminotransferase also known as AST or alkaline aminotransferase is an important enzyme in amino acid metabolism. It catalyzes the transfer of an amino group from aspartate to alpha-ketoglutarate forming glutamate and oxaloacetate. This enzyme has an approximate molecular mass of 46 kDa and is expressed in the liver heart skeletal muscle and kidney tissues. AST plays a significant role in the intracellular balance of amino acids and is an important biomarker in clinical diagnostics.

Biological function summary

AST functions in the transamination process a mechanism central to the synthesis and degradation of amino acids. This process is fundamental in the production of energy and the maintenance of the urea cycle. AST does not form a part of a complex but interacts dynamically with substrates and cofactors like pyridoxal phosphate essential for its enzymatic activity. The activity of AST is important in ensuring the proper function of amino acid metabolism in various tissues.

Pathways

AST operates within the citric acid cycle and the urea cycle. In the citric acid cycle AST contributes to the interconversion of amino acids and metabolic intermediates aiding in energy production. It links to proteins such as malate dehydrogenase and glutamate dehydrogenase which play roles in associated metabolic conversions and energy cycles. These interactions reflect AST's integration in maintaining cellular metabolic processes.

AST levels serve as an indicator of liver health and are often elevated in conditions such as hepatitis and myocardial infarction. Hepatitis causes liver damage resulting in increased AST release into the bloodstream. In myocardial infarction damaged cardiac tissue releases AST providing a diagnostic cue for tissue injury. Elevated AST levels can associate with other enzymes like alanine aminotransferase (ALT) used together to assess liver and heart function.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.

See full target information GOT2

其他靶点

Aspartate aminotransferase, cytoplasmic

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详情请参阅我们的条款与条件。

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重组Alexa Fluor® 555荧光Anti-Aspartate Aminotransferase + FABP-1抗体[EPR12145]