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AB49947

Anti-Aldosterone 3抗体

Anti-Aldosterone 3 antibody

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(1 Publication)

Rabbit Polyclonal Aldosterone 3 antibody. Suitable for RIA and reacts with Chemical samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to Aldosterone 3.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

应用

RIA

applications

特异性

<p>Cross Reactivity: 11- Deoxycorticosterone 1&#46;1% Estradiol &lt; 0&#46;001% 11- Deoxycortisol &lt; 0&#46;001% Androsterone &lt; 0&#46;001% 21- Deoxycortisol &lt; 0&#46;001% Estriol &lt; 0&#46;001% Cortisone &lt; 0&#46;001% Estrone &lt; 0&#46;001% Testosterone &lt; 0&#46;01% Dihydrotesterone &lt; 0&#46;001%</p>

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" } } }

性能和储存信息

形式
Liquid
纯度
Whole antiserum
存储溶液
Constituents: Whole serum
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle|Store in the dark

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Aldosterone 3 known also as CYP11B2 is an enzyme involved in the biosynthesis of aldosterone. It belongs to the cytochrome P450 family and exhibits a mass of approximately 58 kDa. The enzyme is highly expressed in the zona glomerulosa of the adrenal cortex where it facilitates the conversion of corticosterone to aldosterone by catalytic hydroxylation processes. The key role of Aldosterone 3 in this conversion highlights its important enzymatic function in steroid hormone production.
Biological function summary

The process of converting corticosterone into aldosterone by CYP11B2 contributes significantly to the regulation of blood pressure and fluid balance. This enzyme operates within a complex of electron transfer proteins ensuring the supply of electrons for effective catalysis. It partners with adrenodoxin and adrenodoxin reductase to perform its functions. This cooperation allows for the precise control of aldosterone release into the bloodstream affecting the balance of sodium and potassium.

Pathways

Aldosterone 3 plays an important role in the renin-angiotensin-aldosterone system (RAAS) which is central to cardiovascular regulation and fluid homeostasis. Within this pathway CYP11B2 activity links closely with angiotensin II a peptide that stimulates its expression and action. RAAS integrates the function of other proteins such as aldosterone synthase connecting several feedback mechanisms that control blood pressure.

Mutations or dysregulation in CYP11B2 are linked to conditions like primary aldosteronism and hypertension. Alterations in Aldosterone 3 activity lead to imbalances in aldosterone secretion which can cause high blood pressure or contribute to cardiovascular diseases. The enzyme’s relationship with angiotensin-converting enzyme (ACE) through RAAS adds complexity to how it impacts disease processes bridging connections between genetic molecular and systemic levels in the development of these health conditions.

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The FEBS journal 281:1750-8 PubMed24495014

2014

Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Fan,Bing Shen,Mingyue Tan,Xinyu Mu,Yan Qin,Fang Zhang,Yong Liu
View all publications

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