Anti-Aldose reductase抗体(ab175394)
Key features and details
- Rabbit polyclonal to Aldose reductase
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Aldose reductase抗体
参阅全部 Aldose reductase 一抗 -
描述
兔多克隆抗体to Aldose reductase -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human
预测可用于: Rabbit, Pig
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免疫原
Recombinant full length protein corresponding to Human Aldose reductase aa 1-316.
Sequence:MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQ NENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDL KLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVD EGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYC QSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLI RFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA LLSCTSHKDYPFHEEF
Database link: P15121 -
阳性对照
- Human liver extract.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading... -
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab175394于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/50 - 1/200.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
|
| WB |
1/500 - 1/2000. Predicted molecular weight: 35 kDa.
|
| 说明 |
|---|
|
IHC-P
1/50 - 1/200. ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
|
WB
1/500 - 1/2000. Predicted molecular weight: 35 kDa. |
靶标
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功能
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. -
组织特异性
Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. -
序列相似性
Belongs to the aldo/keto reductase family. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 231 Human
- Entrez Gene: 396816 Pig
- Entrez Gene: 100009122 Rabbit
- Omim: 103880 Human
- SwissProt: P15121 Human
- SwissProt: P80276 Pig
- SwissProt: P15122 Rabbit
- Unigene: 521212 Human
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别名
- ADR antibody
- AKR1B 1 antibody
- Akr1b1 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Aldose reductase antibody (ab175394)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human esophageal cancer tissue labelling Aldose reductase with ab175394 at 1/200. Magnification: 200x.
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Western blot - Anti-Aldose reductase antibody (ab175394)Anti-Aldose reductase antibody (ab175394) at 1/500 dilution + Human liver extract
Predicted band size: 35 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (8)
ab175394 被引用在 8 文献中.
- Deng M et al. Scutellarin acts on the AR-NOX axis to remediate oxidative stress injury in a mouse model of cerebral ischemia/reperfusion injury. Phytomedicine 103:154214 (2022). PubMed: 35689902
- Leung D et al. Platinum-resistance in epithelial ovarian cancer: an interplay of epithelial-mesenchymal transition interlinked with reprogrammed metabolism. J Transl Med 20:556 (2022). PubMed: 36463238
- Koike S et al. Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain. Brain Res Bull 144:164-170 (2019). PubMed: 30508605
- Samaddar S & Koneri R Polyphenols of marine red macroalga Symphyocladia latiuscula ameliorate diabetic peripheral neuropathy in experimental animals. Heliyon 5:e01781 (2019). PubMed: 31193485
- He J et al. The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation. Acta Pharmacol Sin N/A:N/A (2018). PubMed: 29930278
- Chen X et al. AKR1B1 Upregulation Contributes to Neuroinflammation and Astrocytes Proliferation by Regulating the Energy Metabolism in Rat Spinal Cord Injury. Neurochem Res 43:1491-1499 (2018). PubMed: 29948725
- Morgenstern J et al. Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells. J Biol Chem 292:3224-3238 (2017). PubMed: 27956549
- Zhao Y et al. Proteomic analysis revealed the altered kidney protein profile of a Cyld knockout mouse model. Genet Mol Res 14:5970-8 (2015). PubMed: 26125796