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AB224360

Anti-ALDH9A1抗体

Anti-ALDH9A1 antibody

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Rabbit Polyclonal ALDH9A1 antibody. Suitable for IHC-P, WB and reacts with Human, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human ALDH9A1 aa 250-450.

查看别名

ALDH4, ALDH7, ALDH9, ALDH9A1, 4-trimethylaminobutyraldehyde dehydrogenase, TMABA-DH, TMABALDH, Aldehyde dehydrogenase E3 isozyme, Aldehyde dehydrogenase family 9 member A1, Formaldehyde dehydrogenase, Gamma-aminobutyraldehyde dehydrogenase, R-aminobutyraldehyde dehydrogenase

3 Images
Western blot - Anti-ALDH9A1 antibody (AB224360)
  • WB

Unknown

Western blot - Anti-ALDH9A1 antibody (AB224360)

All lanes:

Western blot - Anti-ALDH9A1 antibody (ab224360) at 0.4 µg/mL

All lanes:

Rat cell line NBT-II

Predicted band size: 54 kDa

false

Western blot - Anti-ALDH9A1 antibody (AB224360)
  • WB

Unknown

Western blot - Anti-ALDH9A1 antibody (AB224360)

All lanes:

Western blot - Anti-ALDH9A1 antibody (ab224360) at 0.4 µg/mL

All lanes:

Human cell line TD47D

Predicted band size: 54 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH9A1 antibody (AB224360)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH9A1 antibody (AB224360)

Paraffin-embedded human liver tissue stained for ALDH9A1 with ab224360 at 1/200 dilution in immunohistochemical analysis.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Rat, Human

应用

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human ALDH9A1 aa 250-450. The exact immunogen used to generate this antibody is proprietary information.

P49189

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ALDH9A1 also known as aldehyde dehydrogenase 9 family member A1 is an enzyme with a molecular mass of approximately 56 kDa. It catalyzes the conversion of aldehydes to carboxylic acids using NAD+ as a cofactor. ALDH9A1 is found in various tissues including the liver brain and kidney where it plays a role in the detoxification processes and metabolism of aldehydes which can be toxic to cells if not properly managed.
Biological function summary

Aldehyde dehydrogenase 9 family member A1 contributes to cellular homeostasis and plays a protective role by processing aldehydes derived from alcohol metabolism and lipid peroxidation. It forms part of the larger aldehyde dehydrogenase family but it does not appear to engage in complex formations with other proteins in any significant manner. ALDH9A1 also assists in the degradation of histidine and proline amino acids that require processing for proper cellular function.

Pathways

ALDH9A1 is significantly involved in the metabolic pathways of amino acids and fatty acids. In these pathways it is closely related to other aldehyde dehydrogenase proteins like ALDH2 which is active in metabolizing acetaldehyde within the alcohol metabolism pathway. Both ALDH9A1 and these proteins help maintain the balance of aldehyde concentrations ensuring no cellular damage occurs due to aldehyde accumulation.

ALDH9A1 has been implicated in neurological conditions such as Parkinson's disease due to its role in preventing aldehyde-induced oxidative stress. Additionally ALDH9A1 may be relevant to certain types of cancers where aldehyde metabolism disrupts normal cellular functions. Interestingly its relation to these diseases often connects it to proteins like ALDH2 which has similar detoxification roles. Understanding its interactions and contributions in these contexts remains an ongoing area of research.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.
See full target information ALDH9A1
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