AB190298

Anti-ALDH1L1抗体- Astrocyte Marker

Name: ALDH1L1抗体- Astrocyte Marker (ab190298)| Abcam中文官网
Brand: Abcam Limited
SKU: AB190298
Price: 4973 CNY
Availability: InStock
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Anti-ALDH1L1 antibody - Astrocyte Marker

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了解详情

(1 Review)

(27 Publications)

Anti-ALDH1L1 antibody - Astrocyte Marker (ab190298) is a rabbit polyclonal antibody detecting ALDH1L1 in Western Blot, ICC/IF. Suitable for Human, Rat.

- Over 10 publications

查看别名

FTHFD, ALDH1L1, Cytosolic 10-formyltetrahydrofolate dehydrogenase, 10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1

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Immunocytochemistry/ Immunofluorescence - Anti-ALDH1L1 antibody - Astrocyte Marker (AB190298)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ALDH1L1 antibody - Astrocyte Marker (AB190298)

Immunofluorescent analysis of human neuron-glial cell mixture cultures labeling ALDH1L1 with ab190298 at 1/2000 (red) and a monoclonal antibody against GFAP (green). Blue is a DNA stain. Astrocytes labeled by ab190298 and anti-GFAP appear yellow.

Supplier Data

Western blot - Anti-ALDH1L1 antibody - Astrocyte Marker (AB190298)

All lanes:

Western blot - Anti-ALDH1L1 antibody - Astrocyte Marker (ab190298) at 1/5000 dilution

All lanes:

Rat liver tissue homogenate

Predicted band size: 99 kDa

Observed band size: ~100 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat, Human

应用

ICC/IF, WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human ALDH1L1.

O75891

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反应性数据

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产品详情

What is this antibody validated in?
Anti-ALDH1L1 antibody - Astrocyte Marker (ab190298) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Rat samples.

What is the molecular weight of ALDH1L1?
Anti-ALDH1L1 - Astrocyte Marker (ab190298) specifically detects a band for ALDH1L1 (UniProt: O75891) at a molecular weight of 99kDa.

Trusted by the scientific community
Anti-ALDH1L1 - Astrocyte Marker (ab190298) was first used in a scientific publication in 2014 and has been cited over 10 times in peer-reviewed journals.

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性能和储存信息

形式

Liquid

纯度

Whole antiserum

存储溶液

Preservative: 0.03% Sodium azide

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ALDH1L1 also known as 10-formyltetrahydrofolate dehydrogenase plays an important role as a metabolic enzyme involved in folate metabolism. Typically ALDH1L1 has a molecular mass of around 100 kDa. You can find this protein expressed strongly in the liver and brain particularly in astrocytes where it serves as a marker for these star-shaped glial cells. The expression of ALDH1L1 indicates its significant presence in these tissues helping researchers identify and study astrocyte function more effectively.

Biological function summary

ALDH1L1 is involved in the one-carbon metabolism pathway contributing to the conversion of formyl groups into CO2. This reaction aids in regulating cellular homeostasis and energy production. Within the biological context ALDH1L1 works independently and does not form a large complex but efficiently interacts with other enzymes involved in folate transformations. Its activity ensures proper folate cycle functioning supporting DNA synthesis and repair.

Pathways

ALDH1L1 importantly integrates into the folate metabolism pathway supporting detoxification and nucleotide biosynthesis. In this pathway ALDH1L1 interacts with the MTHFD1 protein to maintain the balance of one-carbon units necessary for nucleic acid synthesis. Furthermore ALDH1L1 interplays within the methionine cycle influencing the methylation processes important for gene expression and epigenetic regulation.

ALDH1L1 has associations with neurological conditions particularly Alzheimer's disease and glioblastoma. Changes in ALDH1L1 expression levels have implication in the progression of these diseases. In the context of glioblastoma researchers observe altered ALDH1L1 expression alongside traditional astrocyte markers like GFAP in the tumor microenvironment. Understanding ALDH1L1's role in these conditions could provide insights for developing therapeutic strategies targeting astrocyte behavior.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed : 19933275, PubMed : 21238436). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity).

See full target information ALDH1L1

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文献 (27)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:10250 PubMed40133513

2025

Connexin 43 is downregulated in advanced Parkinson's disease in multiple brain regions which correlates with symptoms.

Applications

Unspecified application

Species

Unspecified reactive species

Nataly Hastings,Saifur Rahman,Przemyslaw Aleksander Stempor,Matthew T Wayland,Wei-Li Kuan,Mark R N Kotter

Proceedings of the National Academy of Sciences of the United States of America 122:e2426107122 PubMed40106355

2025

Androgen receptors in corticotropin-releasing hormone neurons mediate the sexual dimorphism in restraint-induced thymic atrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Yutong Meng,Yaning Li,Huating Gu,Ziyao Chen,Xiaoyang Cui,Xiaodong Wang

Acta neuropathologica communications 13:25 PubMed39934841

2025

Neuropathological stages of neuronal, astrocytic and oligodendrocytic alpha-synuclein pathology in Parkinson's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Otero-Jimenez,Marcelina J Wojewska,Lawrence P Binding,Simona Jogaudaite,Sandra Gray-Rodriguez,Alexandra L Young,Steve Gentleman,Javier Alegre-Abarrategui

Acta neuropathologica 148:80 PubMed39648200

2024

Single-cell transcriptomic and neuropathologic analysis reveals dysregulation of the integrated stress response in progressive supranuclear palsy.

Applications

Unspecified application

Species

Unspecified reactive species

Kristen Whitney,Won-Min Song,Abhijeet Sharma,Diana K Dangoor,Kurt Farrell,Margaret M Krassner,Hadley W Ressler,Thomas D Christie,Shrishtee Kandoi,Ruth H Walker,Melissa J Nirenberg,Steven J Frucht,Giulietta M Riboldi,Bin Zhang,Ana C Pereira,John F Crary

The Journal of neuroscience : the official journal of the Society for Neuroscience 44: PubMed38388424

2024

Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Mark A Deehan,Josine M Kothuis,Ellen Sapp,Kathryn Chase,Yuting Ke,Connor Seeley,Maria Iuliano,Emily Kim,Lori Kennington,Rachael Miller,Adel Boudi,Kai Shing,Xueyi Li,Edith Pfister,Christelle Anaclet,Michael Brodsky,Kimberly Kegel-Gleason,Neil Aronin,Marian DiFiglia

The Journal of cell biology 223: PubMed38334983

2024

APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size.

Applications

Unspecified application

Species

Unspecified reactive species

Ian A Windham,Alex E Powers,Joey V Ragusa,E Diane Wallace,Maria Clara Zanellati,Victoria H Williams,Colby H Wagner,Kristen K White,Sarah Cohen

Annals of neurology 95:558-575 PubMed38069470

2023

FXTAS Neuropathology Includes Widespread Reactive Astrogliosis and White Matter Specific Astrocyte Degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Brett D Dufour,Trevor Bartley,Erin McBride,Erik Allen,Yingratana A McLennan,Randi J Hagerman,Verónica Martínez-Cerdeño

STAR protocols 4:102482 PubMed37561635

2023

Immunofluorescence protocol for localizing protein targets in brain tissue from diverse model and non-model mammals.

Applications

Unspecified application

Species

Unspecified reactive species

Caterina Ciani,Giulio Pistorio,Marika Mearelli,Carmen Falcone

Nature communications 14:3372 PubMed37291151

2023

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Irene Molina-Gonzalez,Rebecca K Holloway,Zoeb Jiwaji,Owen Dando,Sarah A Kent,Katie Emelianova,Amy F Lloyd,Lindsey H Forbes,Ayisha Mahmood,Thomas Skripuletz,Viktoria Gudi,James A Febery,Jeffrey A Johnson,Jill H Fowler,Tanja Kuhlmann,Anna Williams,Siddharthan Chandran,Martin Stangel,Andrew J M Howden,Giles E Hardingham,Veronique E Miron

Cell 185:2213-2233.e25 PubMed35750033

2022

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.

Applications

Unspecified application

Species

Unspecified reactive species

Julia Tcw,Lu Qian,Nina H Pipalia,Michael J Chao,Shuang A Liang,Yang Shi,Bharat R Jain,Sarah E Bertelsen,Manav Kapoor,Edoardo Marcora,Elizabeth Sikora,Elizabeth J Andrews,Alessandra C Martini,Celeste M Karch,Elizabeth Head,David M Holtzman,Bin Zhang,Minghui Wang,Frederick R Maxfield,Wayne W Poon,Alison M Goate

View all publications

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Anti-ALDH1L1抗体- Astrocyte Marker

Anti-ALDH1L1 antibody - Astrocyte Marker

Immunocytochemistry/ Immunofluorescence - Anti-ALDH1L1 antibody - Astrocyte Marker (AB190298)

Western blot - Anti-ALDH1L1 antibody - Astrocyte Marker (AB190298)