AB246928

Anti-ALDH1B1抗体

Name: ALDH1B1抗体 (ab246928)| Abcam中文官网
Brand: Abcam Limited
SKU: AB246928
Price: 5947 CNY
Availability: InStock

Anti-ALDH1B1 antibody

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(2 Publications)

Rabbit Polyclonal ALDH1B1 antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ALDH1B1 aa 1-100.

查看别名

ALDH5, ALDHX, ALDH1B1, Aldehyde dehydrogenase 5, Aldehyde dehydrogenase family 1 member B1

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH1B1 antibody (AB246928)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH1B1 antibody (AB246928)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebral cortex tissue labelling ALDH1B1 with ab246928 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH1B1 antibody (AB246928)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling ALDH1B1 with ab246928 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH1B1 antibody (AB246928)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling ALDH1B1 with ab246928 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Unknown

Immunocytochemistry - Anti-ALDH1B1 antibody (AB246928)

PFA fixed, Triton X-100 permeabilized U-2 OS (Human bone osteosarcoma epithelial cell line) cells labeling ALDH1B1 using ab246928 at 4 μg/ml (green) in ICC/IF.

Supplier Data

Western blot - Anti-ALDH1B1 antibody (AB246928)

All lanes:

Western blot - Anti-ALDH1B1 antibody (ab246928) at 0.04 µg/mL

All lanes:

RH-30 (Human bone marrow metastasis cell line) whole cell lysate

Predicted band size: 57 kDa

Observed band size: 55 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC, IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human ALDH1B1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P30837

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "0.25-2 µg/mL", "ICC-species-notes": "Fixation/Permeabilization: PFA/Triton X-100.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The enzyme ALDH1B1 also known as aldehyde dehydrogenase 1 family member B1 plays a critical role in converting aldehydes to their corresponding carboxylic acids. ALDH1B1 possesses a molecular mass of approximately 56 kDa. This enzyme is expressed in various tissues with particular abundance in the liver and the gastrointestinal tract where it facilitates the detoxification and metabolism of aldehydes.

Biological function summary

This enzyme participates in the oxidation of aldehydes derived from alcohol metabolism enhancing cellular resilience by minimizing toxic aldehyde accumulation. ALDH1B1 occasionally acts as part of larger enzyme complexes where it collaborates with other members of the aldehyde dehydrogenase family to maintain cellular homeostasis and aid in metabolic processes. The enzyme ensures efficient functioning of aldehyde detoxification systems contributing to cellular health.

Pathways

This enzyme is integral to the ethanol metabolism pathway and the one-carbon metabolism pathway. In the ethanol metabolism pathway ALDH1B1 complements other aldehyde dehydrogenase enzymes like ALDH2 converting acetaldehyde to acetate and facilitating safe excretion. In one-carbon metabolism ALDH1B1 influences folate cycle components potentially impacting methylation processes and folate-dependent synthesis pathways. These pathways highlight the enzyme’s role in protecting cells from aldehyde-induced toxicity and maintaining metabolic balance.

ALDH1B1 has been linked to alcohol-related liver disease where its dysfunction may impair acetaldehyde clearance contributing to tissue damage and inflammation. Furthermore abnormal ALDH1B1 activity is associated with colorectal cancer implicating disrupted aldehyde detoxification in tumorigenesis. The enzyme's interaction with proteins such as ALDH2 in these conditions highlights its importance in regulating cellular and tissue health in response to metabolic and alcohol-induced stresses.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.

See full target information ALDH1B1

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Signal transduction and targeted therapy 8:175 PubMed37121942

2023

Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ziruoyu Wang,Yanan Li,Wensi Zhao,Shuai Jiang,Yuqi Huang,Jun Hou,Xuelu Zhang,Zhaoyu Zhai,Chen Yang,Jiaqi Wang,Jiying Zhu,Jianbo Pan,Wei Jiang,Zengxia Li,Mingliang Ye,Minjia Tan,Haowen Jiang,Yongjun Dang

Histology and histopathology 36:183-194 PubMed33438176

2021

Aldehyde dehydrogenase 1B1 is a potential marker of colorectal tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Hejing Wang,Yanmeng Li,Donghu Zhou,Xiaojin Li,Siyu Jia,Saiping Qi,Jian Huang

View all publications

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Anti-ALDH1B1抗体

Anti-ALDH1B1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH1B1 antibody (AB246928)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH1B1 antibody (AB246928)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH1B1 antibody (AB246928)

Immunocytochemistry - Anti-ALDH1B1 antibody (AB246928)

Western blot - Anti-ALDH1B1 antibody (AB246928)