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AB106359

Anti-AIFM3抗体

Anti-AIFM3 antibody

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(2 Publications)

Rabbit Polyclonal AIFM3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human AIFM3.

查看别名

AIFL, AIFM3, Apoptosis-inducing factor 3, Apoptosis-inducing factor-like protein

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIFM3 antibody (AB106359)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIFM3 antibody (AB106359)

Immunohistochemistry of AIFM3 in Human brain tissue with ab106359 at 20 ug/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIFM3 antibody (AB106359)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIFM3 antibody (AB106359)

Immunohistochemical staining of human brain tissue using ab106359 at 2.5 μg

Western blot - Anti-AIFM3 antibody (AB106359)
  • WB

Unknown

Western blot - Anti-AIFM3 antibody (AB106359)

Lane 1:

Western blot - Anti-AIFM3 antibody (ab106359) at 1 µg/mL

Lane 2:

Western blot - Anti-AIFM3 antibody (ab106359) at 2 µg/mL

All lanes:

Human brain tissue lysate at 15 µg

Predicted band size: 15 kDa,19 kDa,26 kDa,39 kDa,45 kDa,59 kDa,66 kDa,68 kDa,72 kDa,76 kDa

Observed band size: 15 kDa,26 kDa,40 kDa,60 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human AIFM3. The exact immunogen used to generate this antibody is proprietary information.

Q96NN9

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搭配使用产品

Primary Antibodies

AB134157

Anti-Cathepsin S antibody [EPR5128]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cathepsin S antibody [EPR5128] (AB134157)

  • 4
  • 1
Primary Antibodies

AB75852

Anti-Cathepsin D antibody [EPR3057Y]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Western blot - Anti-Cathepsin D antibody [EPR3057Y] (AB75852)

  • 5
  • 11
Primary Antibodies

AB125067

Anti-Cathepsin B antibody [EPR4323]

RabMAb|Recombinant|20ul selling size|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Cathepsin B antibody [EPR4323] (AB125067)

  • 0
  • 0
Primary Antibodies

AB76245

Anti-Galectin 3 antibody [EP2775Y]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Galectin 3 antibody [EP2775Y] (AB76245)

  • 5
  • 6
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
Up to 12 months
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

AIFM3 also known as apoptosis-inducing factor mitochondrion-associated 3 is a protein that plays a role in mitochondrial function. It has a molecular mass of approximately 67 kDa. AIFM3 is expressed in several tissues with a significant presence in mitochondria. This protein shares some functional similarity with its family member AIFM1 although it possesses distinct characteristics and functions.
Biological function summary

AIFM3 contributes to cellular processes by participating in apoptosis and energy metabolism. It acts independently or in conjunction with other mitochondrial proteins. It’s not typically part of larger complex like some other apoptosis-inducing factors but it still plays a significant role in maintaining cell viability and influencing how cells respond to stress signals.

Pathways

AIFM3 interacts with important mitochondrial pathways and shows involvement in oxidative phosphorylation and apoptotic processes. Its function often relates to proteins like CYCS and BAX which also engage in apoptosis regulation. The exact mechanisms through which AIFM3 acts within these pathways continue to be an area of active research and interest.

Researchers have linked AIFM3 to conditions such as cancer and neurodegenerative diseases. In some cancers altered expression of AIFM3 can affect cell death impacting tumor growth and progression. It also connects to neurodegenerative conditions through shared pathways with proteins such as APP and BCL2 which influence cellular stress responses. Understanding these relationships helps in exploring potential therapeutic targets for these diseases.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.
See full target information AIFM3
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in medicine 12:1628260 PubMed41070072

2025

REDD1 attenuates cholestatic liver fibrosis and suppresses PI3K/AKT/mTOR pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaonan Li,Xin Liu,Xinrui Shi,Zixu Li,Qizhi Shuai,Tingjuan Huang,Yun Liu,Junjie Ren

Cancers 13: PubMed33435319

2021

Comprehensive Assessment of Copy Number Alterations Uncovers Recurrent and Copy Gain in Medullary Thyroid Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Aline Neves Araujo,Cléber Pinto Camacho,Thais Biude Mendes,Susan Chow Lindsey,Lais Moraes,Marta Miyazawa,Rosana Delcelo,Renata Pellegrino,Diego Robles Mazzotti,Rui Monteiro de Barros Maciel,Janete Maria Cerutti
View all publications
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