AB231040

Anti-Ahsp抗体

Name: Ahsp抗体 (ab231040)| Abcam中文官网
Brand: Abcam Limited
SKU: AB231040
Price: 4748 CNY
Availability: InStock

Anti-Ahsp antibody

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal Erythroid associated factor antibody. Suitable for WB, IHC-P and reacts with Rat, Recombinant full length protein - Rat, Mouse samples. Cited in 1 publication.

查看别名

Ahsp

5 Images

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ahsp antibody (AB231040)

Paraffin-embedded rat kidney tissue stained for Ahsp with ab231040 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ahsp antibody (AB231040)

Paraffin-embedded rat stomach tissue stained for Ahsp with ab231040 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ahsp antibody (AB231040)

Paraffin-embedded rat liver tissue stained for Ahsp with ab231040 at 10 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Ahsp antibody (AB231040)

All lanes:

Western blot - Anti-Ahsp antibody (ab231040) at 3 µg/mL

All lanes:

Recombinant rat Ahsp protein

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit antibody at 1/2000 dilution

false

Supplier Data

Western blot - Anti-Ahsp antibody (AB231040)

All lanes:

Western blot - Anti-Ahsp antibody (ab231040) at 3 µg/mL

Lane 1:

Rat liver lysate

Lane 2:

Mouse liver lysate

Secondary

All lanes:

HRP-linked Guinea pig Anti-Rabbit IgG at 1/2000 dilution

Predicted band size: 12 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat

应用

IHC-P, WB

applications

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Recombinant full length protein - Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab231040 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

存储溶液

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The AHSP protein also known as Alpha Hemoglobin Stabilizing Protein plays an important role in the stabilization of alpha-globin chains. This protein has a mass of approximately 11 kDa and is expressed in erythroid cells which are involved in red blood cell development and function. By binding to alpha-globin the AHSP protein assists in preventing harmful aggregation and degradation of these chains which is important in hemoglobin assembly and stability.

Biological function summary

AHSP protein assists in preventing the precipitation of excess free alpha-globin chains within erythroid cells. It acts as a chaperone guiding the proper folding of alpha-globin and facilitating the formation of hemoglobin. This protein does not work alone; it operates as a component of the erythrocytic protein maturation complex working closely with beta-globin during erythropoiesis to ensure effective hemoglobin production.

Pathways

The AHSP protein integrates into cellular processes by playing a role in the hemoglobin synthesis pathway. It is a part of the broader erythroid differentiation pathway and ensures effective erythrocyte maturation and function. AHSP protein is related to HBA1 and HBA2 proteins through these pathways as they are all important components during hemoglobin formation.

Malfunction or reduced expression of the AHSP protein links to various hemoglobinopathies such as beta-thalassemia and alpha-thalassemia. In these conditions imbalances in the globin chains cause abnormal erythrocyte formation and impaired oxygen transport. The AHSP protein connects to HBB and HBA1 proteins when considering these disorders as its stabilizing role influences the equilibrium between alpha- and beta-globin chains important for effective erythrocyte functionality.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

See full target information Erythroid associated factor

style

left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Biomedicines 9: PubMed34944635

2021

Comparative Proteomic Analysis of tPVAT during Ang II Infusion.

Applications

Unspecified application

Species

Unspecified reactive species

Xiuying Liang,Haijing Guan,Jingwen Sun,Yan Qi,Wenjuan Yao

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Ahsp抗体

Anti-Ahsp antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ahsp antibody (AB231040)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ahsp antibody (AB231040)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ahsp antibody (AB231040)

Western blot - Anti-Ahsp antibody (AB231040)

Western blot - Anti-Ahsp antibody (AB231040)