JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB234817

Anti-AHRR 抗体

Anti-AHRR antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal AHRR antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AHRR aa 250-550.

查看别名

BHLHE77, KIAA1234, AHRR, Aryl hydrocarbon receptor repressor, AhR repressor, AhRR, Class E basic helix-loop-helix protein 77, bHLHe77

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-AHRR antibody (AB234817)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-AHRR antibody (AB234817)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for AHRR (green) using ab234817 at 1/100 dilution in ICC/IF, followed by Alexa Fluor® 488 conjugated Goat Anti-Rabbit IgG (H+L).

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human AHRR aa 250-550. The exact immunogen used to generate this antibody is proprietary information.

A9YTQ3

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
纯化说明
Purity >95%.
存储溶液
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The aryl hydrocarbon receptor repressor (AHRR) is a protein that functions by inhibiting the activity of the aryl hydrocarbon receptor (AHR). It achieves this by competing with AHR for binding to AHR nuclear translocator (ARNT) forming a complex that prevents AHR from activating its target genes. AHRR weighs approximately 78 kDa and is expressed in various tissues particularly in those with a high exposure to environmental toxins such as the liver and lungs. This expression pattern suggests its role in modulating responses to external chemicals.
Biological function summary

AHRR is essential in regulating gene expression involved in responses to xenobiotics. It is part of the AHR signaling complex functioning as a feedback inhibitor that controls the extent and duration of AHR-mediated transcriptional activity. By doing so AHRR helps maintain cellular homeostasis and protects against potential harmful effects of excessive activation of AHR pathways. It also influences the differentiation and function of immune cells and has roles in development and metabolism.

Pathways

AHRR is integral in the xenobiotic metabolism and dioxin signaling pathways. These pathways involve the detoxification processes of harmful compounds. AHRR interacts with proteins like AHR and ARNT to modulate these pathways ensuring that cells respond correctly to environmental pollutants. Through these interactions AHRR also influences the balance of cellular proliferation and apoptosis acting to maintain physiological functions and prevent toxicity.

AHRR has associations with cancer and autoimmune diseases. Dysregulation of AHRR expression can lead to increased susceptibility to cancers as AHR activity becomes unchecked promoting tumor growth and progression. Additionally aberrant AHRR function is linked with autoimmune disorders due to its role in controlling immune system activities. AHRR interacts closely with AHR and ARNT in these disease contexts highlighting the importance of its regulatory functions in maintaining health.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
See full target information AHRR
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:23847 PubMed40615482

2025

Ring-finger protein RNF126 promotes prostate cancer progression via regulation of MBNL1.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Jiang,Ji Li,Jiali Zhang,Yulei Zhao,Guoqin He,Xiaohui Yao

Cancers 16: PubMed39199657

2024

Development of Ex Vivo Analysis for Examining Cell Composition, Immunological Landscape, Tumor and Immune Related Markers in Non-Small-Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Elena G Ufimtseva,Margarita S Gileva,Ruslan V Kostenko,Vadim V Kozlov,Lyudmila F Gulyaeva
View all publications
style
left-column
style
left-column
style
right-column

搭配使用产品

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB190797

Anti-Aryl hydrocarbon Receptor antibody [EPR7119(N)(2)]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Aryl hydrocarbon Receptor antibody [EPR7119(N)(2)] (AB190797)

  • 0
  • 0
Primary Antibodies

AB182422

Anti-CD163 antibody [EPR19518]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Anti-CD163 antibody [EPR19518] (AB182422)

  • 5
  • 17
Primary Antibodies

AB219650

Anti-PRAME antibody [EPR20330]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRAME antibody [EPR20330] (AB219650)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com