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AB216502

Anti-Adiponectin抗体

Anti-Adiponectin antibody

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(1 Publication)

Rabbit Polyclonal Adiponectin antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ADIPOQ aa 100-200 conjugated to Keyhole Limpet Haemocyanin.

查看别名

ACDC, ACRP30, APM1, GBP28, ADIPOQ, Adiponectin, 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, Adipose most abundant gene transcript 1 protein, Gelatin-binding protein, apM-1

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin antibody (AB216502)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin antibody (AB216502)

Immunohistochemical analysis of formalin-fixed and paraffin embedded human colon carcinoma tissue labeling Adiponectin using ab216502 at 1/200, followed by secondary detection and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin antibody (AB216502)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin antibody (AB216502)

Immunohistochemical analysis of formalin-fixed and paraffin embedded mouse liver tissue labeling Adiponectin using ab216502 at 1/200, followed by secondary detection and DAB staining.

Western blot - Anti-Adiponectin antibody (AB216502)
  • WB

Supplier Data

Western blot - Anti-Adiponectin antibody (AB216502)

All lanes:

Western blot - Anti-Adiponectin antibody (ab216502) at 1/200 dilution

Lane 1:

rat liver lysate

Lane 2:

mouse intestine lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP Conjugated at 1/3000 dilution

Predicted band size: 26 kDa

false

Western blot - Anti-Adiponectin antibody (AB216502)
  • WB

Supplier Data

Western blot - Anti-Adiponectin antibody (AB216502)

All lanes:

Western blot - Anti-Adiponectin antibody (ab216502) at 1/300 dilution

All lanes:

Mouse spleen lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP Conjugated at 1/5000 dilution

Predicted band size: 26 kDa

false

Western blot - Anti-Adiponectin antibody (AB216502)
  • WB

Supplier Data

Western blot - Anti-Adiponectin antibody (AB216502)

All lanes:

Western blot - Anti-Adiponectin antibody (ab216502) at 1/300 dilution

All lanes:

mouse heart lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP Conjugated at 1/5000 dilution

Predicted band size: 26 kDa

false

Western blot - Anti-Adiponectin antibody (AB216502)
  • WB

Supplier Data

Western blot - Anti-Adiponectin antibody (AB216502)

All lanes:

Western blot - Anti-Adiponectin antibody (ab216502) at 1/300 dilution

All lanes:

HepG2 cell lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP Conjugated at 1/5000 dilution

Predicted band size: 26 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Rat, Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human ADIPOQ aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q15848

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替代产品

Primary Antibodies

AB181281

Anti-Adiponectin antibody [EPR17019]

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Flow Cytometry (Intracellular) - Anti-Adiponectin antibody [EPR17019] (AB181281)

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Western blot - Anti-Adiponectin antibody [EPR3218] (AB133347)

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  • 0
Primary Antibodies

AB227051

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Flow Cytometry (Intracellular) - Anti-Adiponectin antibody [EPR17019] - BSA and Azide free (AB227051)

  • 0
  • 0

搭配使用产品

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FABP4 antibody [EPR3579] (AB92501)

  • 4
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Primary Antibodies

AB310323

Anti-PPAR gamma antibody [EPR25862-79]

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Adiponectin also known as ADIPOQ or adipocyte complement-related protein of 30 kDa (Acrp30) is a 30 kDa protein that plays a significant mechanical role in energy homeostasis. Adiponectin is secreted predominantly by adipose tissue and circulates in the blood. This protein forms various multimeric structures including low-molecular-weight medium-molecular-weight and high-molecular-weight forms each with distinct biological functions. Its expression in adipose tissue links it closely to metabolic processes and functions related to fat storage and energy balance.
Biological function summary

Adiponectin influences glucose regulation and fatty acid oxidation. It acts as a hormone with several metabolic roles including anti-diabetic anti-atherogenic and anti-inflammatory properties. Adiponectin participates in forming a complex with other proteins such as AdipoR1 and AdipoR2 which are receptors facilitating signal transduction. The interaction of adiponectin with its receptors leads to the induction of several lipid and glucose metabolism pathways important for maintaining cellular energy balance.

Pathways

Many regulatory cascades are influenced by adiponectin. This protein is integral to the AMPK signaling pathway and the PPAR signaling pathway. In the AMPK pathway adiponectin enhances insulin sensitivity and stimulates oxidation of fatty acids in muscle tissue. Through the PPAR pathway it influences lipid metabolism and storage. Adiponectin interacts with key proteins such as leptin and resistin coordinating various metabolic pathways to balance energy and glucose levels making it a critical factor in metabolic regulation.

Reduced levels of adiponectin associate with conditions like type 2 diabetes and cardiovascular disease. Lower circulating adiponectin concentrations correlate with obesity leading to increased insulin resistance and higher risk of type 2 diabetes. In cardiovascular disease this protein's role links to its anti-inflammatory properties and ability to decrease the proliferation of vascular smooth muscle cells. Adiponectin also interacts with proteins like cytokines that play a role in these conditions affecting the body’s inflammatory responses and metabolic processes highlighting its importance in health and disease management.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
See full target information ADIPOQ
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy. Nucleic acids 13:154-163 PubMed30290307

2018

miR-409 Inhibits Human Non-Small-Cell Lung Cancer Progression by Directly Targeting SPIN1.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Song,Quanbo Ji,Jingbo Xiao,Fang Li,Lingxiong Wang,Yin Chen,Yameng Xu,Shunchang Jiao
View all publications
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