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AB288377

重组Anti-Adenosine A1 Receptor抗体[10D12]

Anti-Adenosine A1 Receptor antibody [10D12]

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Rabbit Recombinant Monoclonal Adenosine A1 Receptor antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human ADORA1.

查看别名

Adenosine receptor A1, ADORA1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adenosine A1 Receptor antibody [10D12] (AB288377)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adenosine A1 Receptor antibody [10D12] (AB288377)

IHC image of ab288377 diluted at 1 : 100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

10D12

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human ADORA1. The exact immunogen used to generate this antibody is proprietary information.

P30542

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搭配使用产品

Primary Antibodies

AB3461

Anti-Adenosine Receptor A2a antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adenosine Receptor A2a antibody (AB3461)

  • 4
  • 2
Primary Antibodies

AB197350

Anti-Adenosine A3 Receptor/A3AR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adenosine A3 Receptor/A3AR antibody (AB197350)

  • 0
  • 0
Primary Antibodies

AB131272

Anti-ACTL6A antibody [EPR7443]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACTL6A antibody [EPR7443] (AB131272)

  • 0
  • 0
Primary Antibodies

AB229671

Anti-Adenosine A2b Receptor/ADORA2B antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adenosine A2b Receptor/ADORA2B antibody (AB229671)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Adenosine A1 Receptor also called A1 adenosine receptor is a G protein-coupled receptor (GPCR) with a mass of approximately 37 kDa. This receptor is primarily responsible for binding adenosine a nucleoside involved in numerous physiological processes. Mechanically the A1 receptor inhibits adenylyl cyclase activity via the Gi/o proteins resulting in decreased intracellular cyclic AMP levels. This receptor is expressed in various tissues including the brain heart and kidneys indicating its widespread physiological roles.
Biological function summary

The A1 receptor plays a significant role in mediating the inhibitory effects of adenosine on neurotransmitter release. It regulates synaptic transmission modulates excitability and protects tissues from excessive stimulation. This receptor does not function alone but is part of complex networks interacting with other proteins such as A2A receptors. A1 adenosine receptor signaling contributes to cardioprotection neuroprotection and regulation of renal blood flow reflecting its importance in maintaining homeostasis.

Pathways

The A1 receptor is essential in the adenosine signaling pathway and myocardial protection pathway. Through these pathways it influences important physiological responses like heart rate and blood flow. It interacts with proteins such as adenosine kinase and adenosine deaminase which regulate adenosine concentration influencing the availability of adenosine for receptor binding. The pathways involved illustrate the receptor's role in balancing energy supply and demand.

The A1 adenosine receptor is implicated in conditions like cardiac arrhythmias and epilepsy. Its role in reducing excitability and modulating synaptic transmission makes it a potential target for epilepsy treatment. In cardiac arrhythmias it helps regulate heart rate and protects against ischemic damage. The receptor's interactions with A2B receptors emphasize its role in complex disease mechanisms where it balances excitatory and inhibitory signals providing opportunities for therapeutic interventions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Receptor for adenosine (PubMed : 29925945). The activity of this receptor is mediated by G proteins such as GNAI2 which inhibit adenylyl cyclase.
See full target information ADORA1
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Abcam Product Promise

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