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AB151470

Anti-ADCY2 抗体

Anti-ADCY2 antibody

4

(1 Review)

|

(2 Publications)

Rabbit Polyclonal ADCY2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADCY2 aa 400-600.

查看别名

KIAA1060, ADCY2, Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2

2 Images
Western blot - Anti-ADCY2 antibody (AB151470)
  • WB

Unknown

Western blot - Anti-ADCY2 antibody (AB151470)

7.5% SDS PAGE

All lanes:

Western blot - Anti-ADCY2 antibody (ab151470) at 1/1000 dilution

All lanes:

IMR32 whole cell lysate at 30 µg

Predicted band size: 124 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADCY2 antibody (AB151470)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADCY2 antibody (AB151470)

Immunohistochemical analysis of paraffin-embedded OVCA tissue labeling ADCY2 with ab151470 at 1/250 dilution.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human ADCY2 aa 400-600. The exact immunogen used to generate this antibody is proprietary information.

Q08462

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500.00000 - 1/3000.00000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ADCY2 also known as Adenylate Cyclase 2 is an enzyme involved in the synthesis of cyclic adenosine monophosphate (cAMP) from ATP. ADCY2 with a molecular mass of approximately 140 kDa plays an important role in signal transduction. This protein is highly expressed in the brain particularly in areas such as the cortex and the hippocampus. As part of the adenylate cyclase family ADCY2 is one of several isoforms that share similar functions in different tissues.
Biological function summary

ADCY2 contributes to various cellular processes by converting ATP to cAMP an important secondary messenger in cells. It forms part of the larger signalosome complex and interacts with G-protein coupled receptors. By regulating cAMP levels ADCY2 influences processes such as neurotransmitter release and long-term memory formation. It also modulates the activity of protein kinase A impacting several downstream signaling pathways.

Pathways

ADCY2 is integral to G-protein coupled receptor signaling and the cAMP signaling pathway. This pathway plays a fundamental role in transmitting extracellular signals to intracellular responses. ADCY2's activity is closely linked with other proteins like G-proteins and phosphodiesterases which help regulate cAMP levels and downstream cellular responses. In some pathways ADCY2 interacts synergistically with the protein CREB which orchestrates gene transcription in response to cAMP levels.

ADCY2 has been associated with neurological conditions such as depression and schizophrenia. Altered expression or function of ADCY2 can lead to imbalances in cAMP signaling which affect mood regulation and cognitive functions. The protein CREB which ADCY2 influences is also implicated in mood disorders and cognitive impairments. Understanding ADCY2's role in these conditions aids in developing targeted therapies aimed at modulating its expression or activity.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed : 15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).
See full target information ADCY2
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 12: PubMed35625651

2022

Preferential Expression of Ca-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart.

Applications

Unspecified application

Species

Unspecified reactive species

Yosuke Okamoto,Naing Ye Aung,Masahiro Tanaka,Yuji Takeda,Daichi Takagi,Wataru Igarashi,Kuniaki Ishii,Mitsunori Yamakawa,Kyoichi Ono

Theranostics 11:5650-5674 PubMed33897873

2021

Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Zhang,Keke Yu,Lifang Ma,Zijun Qian,Xiaoting Tian,Yayou Miao,Yongjie Niu,Xin Xu,Susu Guo,Yueyue Yang,Zhixian Wang,Xiangfei Xue,Chuanjia Gu,Wentao Fang,Jiayuan Sun,Yongchun Yu,Jiayi Wang
View all publications
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关联产品

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