Anti-ADAMTS6抗体(ab50647)
Key features and details
- Rabbit polyclonal to ADAMTS6
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ADAMTS6抗体
参阅全部 ADAMTS6 一抗 -
描述
兔多克隆抗体to ADAMTS6 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Rat
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免疫原
A synthetic peptide based on the amino end of the catalytic domain of human ADAMTS-6.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: PBS, 50% Glycerol, 2.9% Sodium chloride -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab50647于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000. Predicted molecular weight: 97 kDa.
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| 说明 |
|---|
|
WB
1/1000. Predicted molecular weight: 97 kDa. |
靶标
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组织特异性
Expressed at low levels in placenta and barely detectable in a number of other tissues. -
序列相似性
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 1 PLAC domain.
Contains 5 TSP type-1 domains. -
结构域
The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. -
翻译后修饰
The precursor is cleaved by a furin endopeptidase.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. -
细胞定位
Secreted, extracellular space, extracellular matrix. - Information by UniProt
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数据库链接
- Entrez Gene: 11174 Human
- Entrez Gene: 361886 Rat
- Omim: 605008 Human
- SwissProt: Q9UKP5 Human
- Unigene: 482291 Human
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别名
- A disintegrin and metalloproteinase with thrombospondin motifs 6 antibody
- A Disintigrin And Metalloproteinase with ThromboSpondin motif 6 antibody
- ADAM-TS 6 antibody
see all
图片
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Western blot - Anti-ADAMTS6 antibody (ab50647)All lanes : Anti-ADAMTS6 antibody (ab50647) at 1/1000 dilution
Lane 1 : Cell media from human amnion-derived WISH cells (treated with IL1-beta) at 12 µl
Lane 2 : Cell media from human amnion-derived WISH cells (treated with IL1-beta) at 10 µl
Lane 3 : Cell media from human amnion-derived WISH cells (treated with IL1-beta) at 8 µl
Lane 4 : Cell media from human amnion-derived WISH cells (treated with IL1-beta) at 6 µl
Predicted band size: 97 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab50647 被引用在 1 文献中.
- Turpeinen H et al. Identification of proprotein convertase substrates using genome-wide expression correlation analysis. BMC Genomics 12:618 (2011). WB ; Mouse . PubMed: 22185580