Anti-ADAMTS13抗体(ab71550)
Key features and details
- Rabbit polyclonal to ADAMTS13
- Suitable for: IHC-P, WB
- Reacts with: Mouse
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-ADAMTS13抗体
参阅全部 ADAMTS13 一抗 -
描述
兔多克隆抗体to ADAMTS13 -
宿主
Rabbit -
特异性
This antibody reacts specifically with human 154 kDa ADAMTS13 protein -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Mouse
预测可用于: Human
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免疫原
Synthetic peptide derived from the N-terminal domain of ADAMTS13 protein.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Constituent: Whole serum -
Concentration information loading... -
纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab71550于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use at an assay dependent concentration.
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| WB | (1) |
Use at an assay dependent concentration. Predicted molecular weight: 154 kDa.
|
| 说明 |
|---|
|
IHC-P
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 154 kDa. |
靶标
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功能
Cleaves the vWF multimers in plasma into smaller forms. -
组织特异性
Plasma. Expressed primarily in liver. -
疾病相关
Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP) [MIM:274150]; also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. -
序列相似性
Contains 2 CUB domains.
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 8 TSP type-1 domains. -
结构域
The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.
The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction. -
翻译后修饰
May contain a C-mannosylation site and O-fucosylation sites in the TSP type-1 domains.
The precursor is processed by a furin endopeptidase which cleaves off the pro-domain. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 11093 Human
- Entrez Gene: 279028 Mouse
- Omim: 604134 Human
- SwissProt: Q76LX8 Human
- SwissProt: Q769J6 Mouse
- Unigene: 131433 Human
- Unigene: 330084 Mouse
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别名
- A disintegrin and metalloproteinase with thrombospondin motifs 13 antibody
- A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13 antibody
- A disintegrin like and metalloprotease with thrombospondin type 1 motif 13 antibody
see all
数据表及文件
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Datasheet download
文献 (3)
ab71550 被引用在 3 文献中.
- Abu El-Asrar AM et al. Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy. Molecules 27:N/A (2022). PubMed: 36144730
- Bartoli CR et al. Insights into the mechanism(s) of von Willebrand factor degradation during mechanical circulatory support. J Thorac Cardiovasc Surg N/A:N/A (2013). WB . PubMed: 24139617
- Pos W et al. An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. Blood 115:1640-9 (2010). WB ; Human . PubMed: 20032502
