AB173290

重组Anti-ADAMTS10抗体[EPR11860]

Anti-ADAMTS10 antibody [EPR11860]

RabMAb
Recombinant
了解详情

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Recombinant Monoclonal ADAMTS10 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

查看别名

A disintegrin and metalloproteinase with thrombospondin motifs 10, ADAM-TS 10, ADAM-TS10, ADAMTS-10, ADAMTS10

1 Images

Supplier Data

Western blot - Anti-ADAMTS10 antibody [EPR11860] (AB173290)

All lanes:

Western blot - Anti-ADAMTS10 antibody [EPR11860] (ab173290) at 1/1000 dilution

Lane 1:

Fetal heart lysate at 10 µg

Lane 2:

A549 cell lysate at 10 µg

Predicted band size: 121 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-ADAMTS10 antibody [EPR11860] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR11860

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

style

left-column

性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS10 also referred to as A Disintegrin and Metalloproteinase with Thrombospondin Motifs 10 is a member of the ADAMTS family. This protein has an approximate molecular mass of 110 kDa. The ADAMTS10 protein functions mainly as a metalloprotease involved in the cleavage of extracellular matrix components affecting tissue remodeling and development processes. It is expressed in various tissues including the eyes and heart suggesting its broad role in different physiological contexts.

Biological function summary

ADAMTS10 plays a significant role in maintaining the structure of fibrillin-rich microfibrils which are essential components of the extracellular matrix. It is part of a larger complex involved in cell signaling and tissue integrity. The interaction with fibrillin suggests its involvement in connective tissue maintenance and elastogenesis which is important for normal cellular functions in eye and cardiac tissue.

Pathways

ADAMTS10 provides functionality within fibrillin and microfibril assembly pathways impacting processes like tissue morphogenesis. It associates closely with other matrix proteins like fibrillin-1 and ADAMTSL proteins in these pathways influencing the structural integrity and biomechanical properties of tissues. Additionally its regulation can affect Notch signaling pathways linking to cellular growth and differentiation processes.

ADAMTS10 mutations are linked to Weill-Marchesani syndrome a connective tissue disorder characterized by eye heart and skeletal abnormalities. The protein's activity also associates with glaucoma a condition involving elevated intraocular pressure leading to optic nerve damage. Researchers have noted a connection with LTBP2 (latent-transforming growth factor beta-binding protein 2) in these conditions suggesting that mutations or dysfunctions in this pathway can disrupt fibrillin functions and lead to disease pathogenesis.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.

See full target information ADAMTS10

style

left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 20:e1012535 PubMed39255317

2024

Methylation of KSHV vCyclin by PRMT5 contributes to cell cycle progression and cell proliferation.

Applications

Unspecified application

Species

Unspecified reactive species

Danping Niu,Yuanming Ma,Pengyu Ren,Sijia Chang,Chenhui Li,Yong Jiang,Chunyan Han,Ke Lan

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-ADAMTS10抗体[EPR11860]